谷胱甘肽在干细胞“干性”及调控中的重要作用

Important role of glutathione in stemness and regulation of stem cells

背景:干细胞是机体内具有强大自我更新能力与多向分化潜能的特殊细胞群体。谷胱甘肽作为干细胞内的重要巯基化合物,不仅参与了干细胞的活性氧代谢,同时在干细胞的自我更新与增殖、干细胞的衰老、干细胞多向分化潜能的维持、干细胞分化的调控等方面均发挥着重要作用。目的:探究谷胱甘肽在干细胞中的重要作用。方法:由第一作者在2020年4月以“(glutathione OR gsh)AND stem cell”为英文关键词检索题名/摘要,以“谷胱甘肽,干细胞”为中文关键词检索任意字段,搜索2000至2020期间中国知网全文数据库、维普全文数据库、万方全文数据库和PubMed数据库收录的相关文献,共检索到相关中文文献358篇,英文文献405篇。在删除重复及不符合入选标准的文献后,最终纳入86篇文献进行分析。结果与结论:通过梳理回顾近些年来谷胱甘肽与干细胞的相关研究,发现谷胱甘肽主要在维持干细胞的干性、调控干细胞的分化等方面发挥着重要作用。同时,谷胱甘肽对肿瘤干细胞的作用已经得到验证,为未来还原型谷胱甘肽治疗肿瘤提供了更多证据支持。

BACKGROUND:Stem cells possess the capacities of self-renewal and multiple differentiation.Glutathione,an important sulfhydryl compounds,not only participates in the active oxygen metabolism of stem cells,but also plays an important role in self-renewal,proliferation,aging,stemness maintenance and differentiation regulation of stem cells.OBJECTIVE:To explore the important role of glutathione in stem cells.METHODS:In April 2020,the first author searched the title/abstract with the English keywords of“glutathione or GSH,stem cell”,and searched any field with the Chinese keywords of“glutathione,stem cell”,and searched the related articles included in CNKI,VIP,Wanfang and PubMed databases from 2000 to 2020.A total of 358 Chinese articles and 405 English articles were retrieved.Finally,86 eligible articles were enrolled for the analysis after deleting the repetitive and non-conforming articles.RESULTS AND CONCLUSION:By reviewing the recent studies on glutathione and stem cells,we found that glutathione played an important role in maintaining stemness,regulating the differentiation of stem cells.In addition,effects of glutathione on cancer stem cells have been verified,which provides more evidence for the future treatment of cancer with reduced glutathione.