空间泰森多边形骨支架黏附性及渗透率分析

Analysis of adhesion and permeability of bone scaffold with Voronoi architecture

背景:骨组织工程研究发现,Voronoi骨支架黏附性和渗透率是影响骨组织工程支架的重要参数,良好的黏附性可以保证骨细胞在支架内部的黏附,从而促进骨组织的再生,而优异的渗透率可以促进营养物质及代谢废物在体内的运输。目的:研究Voronoi骨支架的黏附性及渗透率。方法:以Voronoi骨支架为研究对象,通过Rhino软件对其结构进行了建模,同时借助计算流体力学(CFD)方法对骨支架内部的渗透率及黏附性进行了分析,设定种子点数为20,25,30,缩放因子分别为0.4,0.5,0.6,0.7,0.8,探讨孔隙率与渗透率之间的对应关系。结果与结论:①通过Rhino软件设计得到的Voronoi骨支架结构,平均黏附层厚度分布在0.061-0.116 mm之间,其具有一定的黏附能力,其孔隙率在很大程度上是由缩放因子决定的,随缩放因子的不断增加其孔隙率呈上升趋势,在所选结构设计参数范围内,当缩放因子为0.4时,不同种子点数的支架结构孔隙率均最小,分别为33.78%,33.87%,33.90%;当缩放因子为0.8时,不同种子点数的支架结构孔隙率均最大,分别为84.28%,84.35%,84.38%。②孔隙率的增加对支架结构的渗透率产生了明显影响,随孔隙率的增加,骨支架结构的渗透率呈上升趋势,在所设计支架结构中随孔隙率的变化,其渗透率由16.98×10^(-8)m^(2)增长到82.29×10^(-8)m^(2)。③对支架结构的孔隙率与渗透率之间的关系进行拟合,得到孔隙率与渗透率的关系方程,为骨支架渗透率的预测提供了依据,为复杂结构骨支架生物性能的分析提供了参考。

BACKGROUND:Bone tissue engineering research results have found that the adhesion and permeability of Voronoi bone scaffold are important parameters that affect bone tissue engineering scaffolds.Good adhesiveness can ensure bone cells stick to the scaffold,and promote the bone tissue regeneration.Excellent permeability can increase the transportation of nutrients and metabolic waste in the body.OBJECTIVE:To study the adhesiveness and permeability of the bone scaffolds with Voronoi architecture.METHODS:Taking Voronoi bone scaffold as the research object,its structure was modeled by Rhino software.The permeability and adhesion inside the bone scaffold were analyzed by means of computational fluid dynamics.The number of seed points was set to 20,25,30,and the scaling factors were 0.4,0.5,0.6,0.7,0.8,respectively,to explore the correspondence between the porosity and the permeability.RESULTS AND CONCLUSION:(1)The Voronoi bone scaffold structure designed by Rhino software had an average adhesion layer thickness of 0.061-0.116 mm,which had a certain adhesion capacity.Its porosity was largely determined by the scaling factor.With the continuous increase of the scaling factor,the porosity tended to rise.Within the range of the selected structural design parameters,when the scaling factor was 0.4,the porosity of the scaffold with different seed points was the smallest,which was 33.78%,33.87%,and 33.90%,respectively.When the scaling factor was 0.8,the porosity of the scaffold structure with different seed points was the largest,which was 84.28%,84.35%,and 84.38%,respectively.(2)The increase in the porosity had a significant impact on the permeability of the scaffold structure.With the increases of the porosity,the permeability of the bone scaffold structure rose.In the designed scaffold structure,the permeability increased from 16.98×10^(-8)m^(2) to 82.29×10^(-8)m^(2) with the increase of the porosity.(3)The relationship between the porosity of the scaffold structure and the permeability is obtained,which provides a basis for the prediction of the permeability of the bone scaffold and the analysis of the biological performance of the complex structure bone scaffold.