生物材料人血小板裂解液在组织再生修复中的应用与作用

Application and role of human platelet lysate in tissue repair and regeneration

背景:人血小板裂解液富含多种可促进组织损伤修复的物质,是一类可促进组织细胞再生修复的生物材料。目的:总结人血小板裂解液的组成、制备工艺及其近年来在人组织修复中的临床研究与应用进展。方法:第一作者以“human platelet lysate,clinical,trial,regeneration,tissue repair,wound healing,biomaterial”为英文检索词,以“血小板裂解液,临床,临床试验,再生,组织修复,创伤愈合,生物材料”为中文检索词,应用计算机检索PubMed、clinicaltrials.gov、中国临床试验注册中心、维普、万方及知网数据库中2013年1月至2021年3月已发表的相关文献。结果与结论:人血小板裂解液可以从自体外周血、异体外周血或脐血中制备,富含多种促进细胞生长和创伤修复相关生物活性物质。目前发表的临床研究结果表明,单独使用人血小板裂解液或者人血小板裂解液联合细胞治疗在组织修复中均具有安全性和有效性。22项正在进行的临床研究涉及到包括新冠肺炎造成的呼吸窘迫综合征、下肢血管疾病、糖尿病溃疡、面部美容等新的适应证,未来这些临床研究有效性结果将进一步增加人血小板裂解液在组织再生修复中的作用。将人血小板裂解液与组织工程材料相结合,将为其在更大组织缺损的再生修复奠定基础。

BACKGROUND:Human platelet lysate,rich in ingredients of tissue healing,is a class of biomaterials for tissue repair and regeneration.OBJECTIVE:To summarize the composition and preparation of platelet lysate and its recent advances in clinical studies and application in human tissue repair.METHODS:The first author searched PubMed,clinicaltrials.gov,Chinese Clinical Trial Registry,VIP,Wanfang and CNKI databases for relevant articles and clinical trials published from January 2013 to March 2021.The key words were“human platelet lysate,clinical,trial,regeneration,tissue repair,wound healing,biomaterial”in English and Chinese,separately.RESULTS AND CONCLUSION:Human platelet lysate can be prepared from autologous/allogeneic peripheral blood or umbilical cord blood and contains a variety of components that facilitate cell growth and wound healing.Current clinical studies have demonstrated the safety and efficacy of human platelet lysate,alone or in combination with cell therapy,in tissue repair.Totally 22 ongoing clinical trials in clinicaltrials.gov involve the treatment of several new indications,including post-COVID-19 acute respiratory distress syndrome,peripheral arterial disease,diabetic foot ulcer,facial aesthetics,and so on.In future,the efficacy of these clinical studies will further increase the role of human platelet lysate in tissue regeneration and repair.The combination of human platelet lysate with tissue engineering materials will lay the foundation for its regenerative repair in large tissue defects.