盐酸吉西他滨联合替吉奥化疗治疗胆管癌的应用分析

Analysis of the Application of Gemcitabine Hydrochloride Combined with Tigio Chemotherapy in the Treatment of Cholangiocarcinoma

目的探讨盐酸吉西他滨联合替吉奥化疗治疗胆管癌的应用。方法选择我院100例2017年8月至2019年2月胆管癌患者。随机分组,对照组实施盐酸吉西他滨治疗,观察组则在对照组治疗的方案基础上增加了替吉奥。比较两组胆管癌疗效;从治疗开始随访的生存时间;治疗前后患者外周血清免疫因子CD_(4)^(+)、CD_(8)^(+)以及生存质量评分;化疗不良反应发生率。结果观察组胆管癌疗效、从治疗开始随访的生存时间、外周血清免疫因子CD_(4)^(+)、CD_(8)^(+)以及生存质量评分相比较对照组更好,P<0.05。观察组和对照组化疗不良反应发生率相似,P>0.05。结论盐酸吉西他滨联合替吉奥方案对于临床治疗胆管癌患者获得的成效非常明显,相比较单一的吉西他滨,这种联合方案对患者免疫功能有一定的提升作用,可将生存时间延长,且安全性高,未增加不良反应。

Objective To explore the application of gemcitabine hydrochloride combined with tigio chemotherapy in the treatment of cholangiocarcinoma.Methods One hundred patients with cholangiocarcinoma in our hospital from August 2017 to February 2019 were selected.The patients in the control group were randomly divided into two groups:the control group was treated with gemcitabine hydrochloride,and the observation group was treated with tigio on the basis of the treatment in the control group.The curative effect of cholangiocarcinoma was compared between the two groups;the survival time of follow-up from the beginning of treatment;the peripheral serum immune factors CD_(4)^(+),CD_(8)^(+)and Karnofsky health score,quality of life score before and after treatment;and the incidence of side effects of chemotherapy.Results The curative effect of cholangiocarcinoma,the survival time of follow-up from the beginning of treatment,peripheral serum immune factors CD_(4)^(+),CD_(8)^(+),karnofsky health score and quality of life score in the observation group were better than those in the control group(P<0.05).The incidence of side effects of chemotherapy in the observation group was similar to that in the control group(P>0.05).Conclusion Gemcitabine hydrochloride combined with tigio regimen is very effective in the clinical treatment of patients with cholangiocarcinoma.Compared with single gemcitabine,this combination regimen can improve the immune function of patients and prolong the survival time.And high safety,no increase in side effects.