阿立哌唑对急性期精神分裂症患者的非酶抗氧化物及信息处理速度的影响

Effects of aripiprazole on non-enzymatic antioxidants and information processing speed in acute episode of schizophrenia

目的探讨阿立哌唑对急性期精神分裂症患者的非酶抗氧化物及信息处理速度的影响。方法纳入2017年3月~2020年1月住院的精神分裂症患者92例,予6周阿立哌唑单药治疗。评估治疗前后的阳性和阴性症状量表(PANSS)分数,利用符号编码、Stroop色词测验评估信息处理速度,并检测血清白蛋白、总胆红素、尿酸浓度。分别比较治疗前后患者非酶抗氧化物浓度及信息处理速度的差异,并探讨其与临床疗效的关联。结果①、经6周治疗,PANSS总分(t=-22.74,P<0.001)及血清白蛋白(t=-2.46,P=0.016)、总胆红素(t=-3.88,P<0.001)、尿酸(t=-5.23,P<0.001)浓度均较治疗前明显下降;符号编码(t=9.52,P<0.001)、Stroop测验(t=9.70,P<0.001)分数均提高。②、将患者分为治疗有效与无效组,经重复测量方差分析显示,非酶抗氧化物浓度及信息处理速度的时间主效应有统计学意义(均P<0.001),但组别主效应及时间*组别交互效应均无统计学意义(均P>0.05)。结论阿立哌唑可影响急性期精神分裂症患者的非酶抗氧化系统与认知功能,且均与临床疗效无关。

Objective To investigate the effects of aripiprazole on the serum non-enzymatic antioxidants and information processing speed of patients in acute episode of schizophrenia.Methods From March 2017 to January 2020,92 schizophrenia patients in acute episode were enrolled and finished 6 weeks treatment with aripiprazole.Before and after treatment,positive and negative syndrome scale(PANSS)was used to evaluate the clinical symptoms,symbolic coding(SC)and Stroop color-word test(SCWT)were used to evaluate the information processing speed.Serum albumin(ALB),total bilirubin(TBIL)and uric acid(UA)concentrations were also detected.The differences of serum non-enzymatic antioxidant concentration and information processing speed were compared before and after treatment.Further analyses of relationships between non-enzymatic antioxidant,information processing speed and treatment responses were conducted.Results①.The total PANSS scores(t=-22.74,P<0.001),ALB(t=-2.46,P=0.016),TBIL(t=-3.88,P<0.001)and UA(t=-5.23,P<0.001)all decreased significantly after treatment.SC(t=9.52,P<0.001)and SCWT scores(t=9.70,P<0.001)significantly improved.②.Divided the sample into treatment response and non-response group by reducing rate of PANSS,repeated measures analysis of variance showed that there were significant main effects of time on ALB,TBIL,UA,SC and SCWT(all P<0.001),with no significant main effect of group or time*group interaction(all P>0.05).Conclusions Aripiprazole can affect serum non-enzymatic antioxidant and cognitive function in acute episode of schizophrenia,and these processes may be not related to treatment response.