胱抑素C、游离脂肪酸与慢性心衰患者伴发抑郁的相关性

Correlation of cystatin C,free fatty acids and depression in chronic heart failure patients

目的探讨胱抑素C(Cys-C)、游离脂肪酸(FFA)与慢性心衰患者伴发抑郁的相关性。方法本研究对象为2018年4月~2020年4月我院收治的100例慢性心衰患者,采用Zung抑郁自评量表(SDS)进行抑郁筛查,根据结果分为慢性心衰抑郁组以及慢性心衰组,分别为32例、68例。比较两组患者的血清FFA、Cys-C水平以及左心室射血分数(LVEF),并分析血清FFA、Cys-C水平以及LVEF与SDS评分的相关性。结果慢性心衰抑郁组血清FFA、Cys-C水平、SDS评分显著高于慢性心衰组,LVEF显著低于慢性心衰组(P<0.05);血清FFA、Cys-C水平与SDS评分呈正相关,LVEF与SDS评分呈负相关(P<0.05)。结论慢性心衰患者伴发抑郁的检出率较高,高FFA、Cys-C水平以及心脏功能偏低与抑郁情绪的发生相关,有望成为慢性心衰患者伴发抑郁的预测因子。

Objective To explore the correlation between cystatin C(Cys-C),free fatty acid(FFA)and depression in chronic heart failure patients.Methods A total of 100 patients with chronic heart failure in our hospital from April 2018 to April 2020 were selected as the study subjects.The Zung self-rating depression scale(SDS)was used for depression screening,and were set as the chronic heart failure depression group and the chronic heart failure group,with 32 cases and 68 cases respectively.The serum FFA,Cys-C levels and left ventricular ejection fraction(LVEF)were detected.The serum FFA,Cys-C level and the correlation between LVEF and SDS score were analyzed.Results The serum FFA,Cys-C and SDS scores of the chronic heart failure depression group were significantly higher than those of the chronic heart failure group,and LVEF was significantly lower than the chronic heart failure group(P<0.05).Serum FFA and Cys-C levels were positively correlated with SDS score,and LVEF was negatively correlated with SDS score(P<0.05).Conclusion The detection rate of depression in patients with chronic heart failure is relatively high,and high FFA,Cys-C levels and low cardiac function are important to the occurrence of depression.It is expected to be the predictor of chronic heart failure depression.