摘要
In a recent paper published in Science,Mascharak et al.^(1) demonstrated that inhibiting Engrailed-1 activation in wound fibroblasts promotes scarless wound repair that phenocopies wound repair by regeneration seen in lower taxon groups and rarely in mammals.Many living species of chordates,including vertebrates,respond to injury by regenerating a perfect tissue replica.Mammals and humans on the other hand,with some rare exceptions,replaced true regeneration with scar tissue build-up in wounds.
