非传统血脂指标的临床意义应受到关注

The clinical significance of non-traditional lipid parameters should be concerned

动脉粥样硬化性心血管疾病(ASCVD)是导致死亡的首要原因,而血脂异常是ASCVD发生发展的核心机制,并被列为可纠正的心血管疾病危险因素。低密度脂蛋白胆固醇(LDL-C)作为传统的血脂指标被视为ASCVD血脂干预的首要靶标已为人们所熟知,但随机对照和真实世界研究表明,将LDL-C水平控制在当今指南的理想范围内仍存在心血管残余风险。据此,近年来一系列研究发现,尚存新的血脂指标亦与心血管残余风险相关。本文仅就非传统血脂指标,包括脂蛋白α、非高密度脂蛋白胆固醇、载脂蛋白B、残余胆固醇和LDL颗粒中的三酰甘油等在心血管领域的研究现状作一概述。

Atherosclerotic cardiovascular disease(ASCVD)remains the leading cause of human deaths all over the world.Dyslipidemia is the central mechanism of the prevalence and development of ASCVD,which has been regarded as a remediable risk factor for cardiovascular disease.It′s well known that the traditional lipid parameter,low-density lipoprotein cholesterol(LDL-C),is the primary target for lipid interfering in ASCVD.However,both randomized controlled trials and real-world studies have suggested that residual risk persists in spite of the well-controlled LDL-C levels according to current guidelines.Hence,in recent years,a series of studies have indicated that many novel lipid indicators are closely correlated with the residual risk of ASCVD.This article aimed to summarize the research status of these non-traditional lipid parameters in cardiovascular field.