病毒的锌指蛋白在病毒感染中的作用

The Role of Zinc Finger Protein of Virus in Virus Infection

锌指(zinc fingers,ZF)结构是一种广泛存在于动植物、微生物包括许多病毒中的蛋白结构,肽链中氨基酸残基的特征基团与Zn2+结合从而稳定形成一种很短的、可自我折叠成“手指”形状的多肽空间构型。具有ZF结构的蛋白被称为锌指蛋白(zinc-finger protein,ZNF),研究发现,部分病毒可以编码具有ZF结构的蛋白且该蛋白会影响到病毒的复制、成熟病毒粒子的包装释放、调节激活病毒转录和裂解性感染及协助病毒的先天免疫逃逸等。本文就目前病毒的ZNF在病毒感染过程中发挥作用的研究进展作一综述,为ZNF的深入研究及以ZNF为靶位点的抗病毒药物研制提供参考。

Zinc finger(ZF)structure is a kind of common protein structure widely existing in animals,plants,microorganisms including many viruses.The characteristic group of amino acid residues in the peptide chain combines with Zn^(2+),thus forming a very short peptide space configuration which can self fold into"finger"shape.Zinc-finger proteins(ZNF)are proteins with zinc finger structure.It has been found that some viruses can encode zinc finger proteins,which can affect virus replication,packaging and release of mature virus particles,regulate and activate virus transcription and cleavage infection,and assist virus in innate immune escape.In this paper,the research progress of the role of ZNF in the process of virus infection is reviewed,which provides a reference for the further study of ZNF and the development of its targeting antiviral drugs.