羟基磷灰石表面改性作为组织工程骨支架的应用优势

Application advantages of hydroxyapatite surface modification as a bone scaffold for tissue engineering

背景:由于羟基磷灰石与高分子材料的理化性质差异较大、界面相容性差且本身容易聚集,导致复合材料的力学和生物学性能较差,限制了其在组织工程骨中的应用。目的:综述近年来羟基磷灰石表面改性用于制备组织工程骨的方法,并对这些方法的反应机制、作用影响进行简述。方法:在万方、中国知网、维普、PubMed、PubMed Central Medine及谷歌学术等数据库中,以“温敏型凝胶,缓释,给药途径”为中文检索词,以“hydroxyapatite,surface modification,tissue engineered bone”为英文检索词,检索羟基磷灰石表面改性作为组织工程骨支架的研究进展方面的文章。结果与结论:迄今已有多种材料表面改性方法,如表面活性剂、硅烷偶联剂及接枝聚合物等,已经取得一定进展,但是单一一种改性方法的效果仍有限,可考虑将两种或多种改性方法及改性剂结合使用,相互取长补短,取得更好的改性效果。表面改性不仅要改善羟基磷灰石的分散性,提高复合材料的力学性能,还要将具有生物活性、能够促进骨组织再生的生物活性因子、多肽等固定在羟基磷灰石表面,进而改善复合材料的生物学性能,实现对羟基磷灰石性能的调控,制备性能优良的组织工程骨。

BACKGROUND:Due to the large difference in physical and chemical properties between hydroxyapatite and polymer materials,poor interfacial compatibility and easy aggregation,the mechanical and biological properties of the composite materials are poor,which limits the application of hydroxyapatite in tissue engineered bone.OBJECTIVE:To review the methods of surface modification of hydroxyapatite for the preparation of tissue engineered bone in recent years,and to briefly discuss the reaction mechanism and effect of these methods.METHODS:On Wanfang,CNKI,VIP,PubMed Central Medine,Google academic databases,articles on the research progress of hydroxyapatite surface modification as tissue engineered bone scaffold were searched using the Chinese search term of“temperature sensitive gel,slow release,drug delivery pathway”and the English search term of“hydroxyapatite,surface modification,tissue engineered bone”.RESULTS AND CONCLUSION:Up to now,a variety of materials surface modification methods,such as surface active agent,silane coupling agent and grafted polymer,have made some progress,but the effect of a modified method for single is still limited.We can consider putting two or many kinds of modification methods and the modifier in combination to complement each other for a better modification effect.Surface modification is not only to improve the dispersivity of the hydroxyapatite,and increase mechanical properties of the composites,but also will have biological activity,can promote bone regeneration of bioactive factors,such as peptides on the surface of hydroxyapatite,and thus improve the biological properties of composite materials,realize the control on the properties of hydroxyapatite,and the preparation of excellent performance of the tissue engineered bone.