辛伐他汀局部给药治疗牙周炎:装载在药物缓释系统或生物支架系统上的效应

Topical simvastatin administration in the treatment of periodontitis: effect of loading on sustained drug release system or biomaterial scaffold system

背景:传统牙周治疗不能恢复牙周软硬组织,希望探索辛伐他汀局部给药系统对牙周炎的影响,为牙周炎的临床治疗开辟一条新途径。目的:综述辛伐他汀促进牙周骨再生、治疗牙周炎的机制,辛伐他汀局部释药系统、生物材料支架系统、凝胶局部给药系统的优缺点及制备方法。方法:由第一作者以"simvastatin;microspheres;hydrogels;periodontitis;Bone tissue engineering"为英文关键词,以"辛伐他汀;药物缓释;生物材料支架;凝胶系统;牙周炎;骨组织工程"为中文关键词,检索1988-2020年期间收录在PubMed、万方、中国知网等文献数据库的文献,共检索出50篇符合标准的文献进行综述。结果与结论:随着组织工程的发展,实验及临床研究将生长因子、支架材料及载体混合制备出更具生物相容性、流动性、促进骨再生的共聚物,用来协助牙周炎的治疗,取得了良好的效果。在近些年的研究中,一些学者将辛伐他汀装载在药物缓释系统上,一些学者则是将辛伐他汀装载在生物材料支架系统上,另一些学者则将辛伐他汀装载在凝胶给药系统上,这些方法都得到了更好的缓释药物效果,促进了牙周骨的再生。

BACKGROUND: Traditional periodontal therapy cannot restore periodontal soft and hard tissue. It is hoped to explore the effect of local simvastatin administration system on periodontitis, and open up a new way for clinical treatment of periodontitis.OBJECTIVE: To review the mechanisms of simvastatin on promoting periodontal bone regeneration and on treating periodontitis, as well as the advantages, disadvantages and preparation methods of local simvastatin drug delivery system, biomaterial scaffold system and local gel drug delivery system. MEDTHODS: The first author retrieved the articles published from 1988 to 2020 in Pub Med, Wanfang, CNKI and other literature databases. The English key words were "simvastatin;microspheres;hydrogels;periodontitis;bone tissue engineering". The Chinese key words were "simvastatin;sustained drug release;biomaterial scaffold;gel system;periodontitis;bone tissue engineering". A total of 50 articles that met the criteria were included for review. RESULTS AND CONCLUSION: With the development of tissue engineering, experimental and clinical studies have mixed growth factors, scaffold materials and carriers to prepare copolymer with more biocompatibility, fluidity and promotion of bone regeneration, which is used to assist the treatment of periodontitis and has achieved good results. In recent years of research, some scholars loaded simvastatin on sustained release system;some scholars loaded simvastatin on biomaterial stent system;some scholars loaded simvastatin on the gel drug delivery system. All these methods have good slow-release drug effect, and promote the periodontal bone regeneration.