掺锌羟基磷灰石的制备及生物性能

Preparation and biological properties of zinc-doped hydroxyapatite

背景:随着骨组织再生工程研究的发展,人工生物材料在骨缺损修复上的应用越来越广泛,如何改性生物材料使其有更好的机械性能和生物性能,以满足骨缺损修复的临床应用一直是生物材料研究的热点。目的:综述近几年掺锌羟基磷灰石材料的研究进展。方法:以"锌、羟基磷灰石、掺锌羟基磷灰石、体内、体外、抑菌性、骨缺损、Zinc、hydroxyapatite、Zn-HA、in vivo、in vitro、antibacterial activity、bone defect"为中、英文检索词,应用计算机检索CNKI中国期刊全文数据库、Pub Med及FMRS外文医学信息检索平台2000-2020年收录的有关掺锌羟基磷灰石的相关文献。结果与结论:锌掺入羟基磷灰石制备方法有很多,应用较多的是化学沉淀法、水热合成法和溶胶凝胶法。锌掺入后并不会改变羟基磷灰石的晶体结构,但随锌浓度的增加晶体的晶核大小和结晶度逐渐减小。少量锌掺杂可以显著提升羟基磷灰石的生物相容性、生物活性和抑菌活性,而较多锌掺入会引起毒性反应。因此研究应用中要选择合适的制备方法,严格控制反应条件,以制备出符合临床骨缺损修复需求的掺锌羟基磷灰石复合材料。

BACKGROUND: With the development of bone tissue regeneration engineering research, artificial biomaterials are widely used in bone defect repair. How to modify biomaterials to make them have better mechanical and biological properties to meet the clinical application of bone defect repair has always been the focus of biomaterials research.OBJECTIVE: To review the research progress of zinc-doped hydroxyapatite in recent years, in order to provide more references for future scientific research and clinical application.METHODS: The search terms "zinc, hydroxyapatite, zinc-doped hydroxyapatite, in vivo, in vitro, bacteriostasis, bone defect" in English and Chinese were used to retrieve articles on zinc-doped hydroxyapatite published from 2000 to 2020 on CNKI, Pub Med and FMRS using computer. RESULTS AND CONCLUSION: There are many preparation methods of zinc-doped hydroxyapatite, among which chemical precipitation method, hydrothermal synthesis method and sol-gel method are widely used. The crystal structure of hydroxyapatite does not change with the addition of zinc, but with the increase of zinc concentration, the crystal nucleus size and crystallinity gradually decrease. A small amount of zinc doping can significantly improve the biocompatibility, biological activity and antibacterial activity of hydroxyapatite, while a large amount of zinc doping can cause toxic reaction. Therefore, we should choose the appropriate preparation method and strictly control the reaction conditions in the practical research and application to prepare zinc-doped hydroxyapatite composite materials that meet the needs of clinical bone defect repair.