综合老年评估体系对多发性骨髓瘤患者预后价值

The Prognostic Value of Comprehensive Elderly Assessment System for Patients with Multiple Myeloma

目的探讨综合老年评估体系(CGA)对中国老年多发性骨髓瘤患者的预后价值。方法方便选取福建省立医院2015年1月—2020年1月收治的81例年龄(≥65岁)的多发性骨髓瘤患者为研究对象。按照CGA体系积分分为适合组、不适合组、虚弱组。比较3组临床指标。结果3组的ORR分别为88.2%、95.2%、53.5%,差异有统计学意义(χ^(2)=15.022,P<0.001);2年OS率分别是82.4%、81.0%、34.9%,差异有统计学意义(χ^(2)=19.980,P<0.001);2年PFS率分别是52.9%、42.9%、16.3%,差异有统计学意义(χ^(2)=16.850,P<0.001)。虚弱组和不适合组肺部、心血管、血液系统、胃肠道不良反应明显高于适合组。结论CGA体系可预测老年多发性骨髓瘤患者的治疗反应、不良反应及远期生存。

Objective To validate comprehensive gerontological assessment(CGA)system in elderly multiple myeloma(MM)patients.Methods The 81 patients with multiple myeloma aged≥65 years who were admitted to Fujian Provincial hospital from January 2015 to January 2020 were convenience selected as the research objects.According to the CGA system points,they are divided into suitable group,unsuitable group and weak group.To compared climical indicators of the three groups.Results The ORR of the 3 groups were 88.2%,95.2%,and 53.5%,respectively,and the difference was statistically significant(χ^(2)=15.0220,P<0.001);2-year OS rates were 82.4%,81.0%,34.9%,and the difference was statistically significant(χ^(2)=19.980,P<0.001);2-year PFS rates were 52.9%,42.9%,16.3%,the difference was statistically significant(χ^(2)=16.850,P<0.001).The adverse effects of lung,cardiovascular,blood system and gastrointestinal tract in the weak group and the unsuitable group were significantly higher than those in the suitable group.Conclusion CGA system can predict the treatment response,adverse reactions and long-term survival of elderly patients with multiple myeloma.