拉贝洛尔治疗妊娠高血压症的效果及对分娩结局的影响

The Effect of Labetalol in the Treatment of Pregnancy-induced Hypertension and Its Influence on the Outcome of Childbirth

目的探讨拉贝洛尔治疗妊娠高血压症的效果及对分娩结局影响。方法方便选取2018年3月—2019年9月106例妊娠高血压症患者,按数字随机抽取将患者分成两组,分别为对照组(n=53)、观察组(n=53),对照组采用硫酸镁治疗,观察组在对照组基础上采用拉贝洛尔治疗,观察两组患者血压控制情况、治疗效果及分娩结局。结果观察组治疗后收缩压(148.58±27.69)mmHg、舒张压(80.63±29.62)mmHg均低于对照组(161.43±26.51)、(91.91±28.75)mmHg,差异有统计学意义(t=2.440、1.989,P=0.016、0.049);观察组总有效率(98.11%)高于对照组(84.91%),差异有统计学意义(χ^(2)=4.371,P=0.037);观察组产后出血量(201.63±19.26)mL少于对照组(213.95±18.38)mL,差异有统计学意义(t=3.369,P=0.001);观察组新生儿窒息(3.77%)、宫内窘迫(5.66%)、胎盘早剥(1.89%)发生率及剖宫产率(20.75%)均低于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔治疗妊娠高血压症具有明显效果,可预防产后大出血,使血压得到明显控制,可改善分娩结局,而且安全性高。

Objective To investigate the effect of labetalol in the treatment of pregnancy induced hypertension(PIH)and its influence on delivery outcome.Methods From March 2018 to September 2019,106 patients with pregnancy-induced hypertension were conveniently selected and randomly selected according to the numbers.The patients were divided into two groups,namely the control group(n=53)and the observation group(n=53).The control group was treated with magnesium sulfate,and the observation group was treated with labetalol on the basis of the control group.The blood pressure control,treatment effect and delivery outcome of the two groups were observed.Results After treatment,systolic blood pressure(148.58±27.69)mmHg and diastolic blood pressure(80.63±29.62)mmHg in the observation group were lower than those in the control group(161.43±26.51)mmHg and(91.91±28.75)mmHg,and the differences were statistically significant(t=2.440,1.989,P=0.016,0.049);the total effective rate of the observation group(98.11%)was higher than that of the control group(84.91%),and the difference was statistically significant(χ^(2)=4.371,P=0.037).The postpartum blood loss in the observation group(201.63±19.26)mL was less than that in the control group(213.95±18.38)mL,and the difference was statistically significant(t=3.369,P=0.001).The incidence of neonatal asphyxia(3.77%),intrauterine distress(5.66%),placental abruption(1.89%)and cesarean section(20.75%)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Labetalol has obvious effect in the treatment of pregnancy induced hypertension,which can prevent postpartum hemorrhage,control blood pressure,improve delivery outcome,and has high safety,so it can be widely used.