阿加曲班联合阿司匹林及氯吡格雷治疗对急性脑梗死患者神经功能缺损及生活能力的改善分析

Argatroban Combined with Aspirin and Clopidogrel Treatment on Neurological Deficit and Improvement of Life Ability in Patients with Acute Cerebral Infarction

目的研究应用阿加曲班、阿司匹林与氯吡格雷3药联合治疗急性脑梗死神经功能改善的优势性。方法便利选取2018年7月—2020年7月该院收治的76例急性脑梗死患者作为研究对象,根据治疗方案的不同分为两组,各38例。比对组应用阿司匹林联合氯呲格雷抗血小板聚集治疗;探析组阿加曲班抗凝、阿司匹林与氯吡格雷抗血小板聚集联合应用,对比不同治疗方案的诊疗价值。结果治疗后,探析组治疗有效性92.11%高于比对组68.42%,差异有统计学意义(χ^(2)=6.728,P=0.009)。治疗前,两组患者的神经功能缺损评分相比较,差异无统计学意义(t=0.041,P=0.967)。治疗后,探析组神经功能缺损评分低于比对组,差异有统计学意义(t=21.863,P<0.001)。治疗前,两组患者的生活能力评分相比较,差异无统计学意义(t=0.042,P=0.967)。治疗后,探析组生活能力评分低于比对组,差异有统计学意义(t=4.762,P<0.001)。两组在治疗安全性方面,差异无统计学意义(χ^(2)=0.140,P=0.709)。结论阿司匹林及氯吡格雷联合阿加曲班抗血小板聚集、抗凝治疗急性脑梗死效果明显,更可提高患者的生活能力,改善神经功能缺损状况,致残率下降。

Objective To study the advantage of argatroban,aspirin and clopidogrel in the treatment of acute cerebral infarction.Methods From July 2018 to July 2020,there were 76 patients with acute cerebral infarction conveniently selected as object of study,38 cases in the control group were treated with aspirin combined with clopidogrel for antiplatelet aggregation,and 38 cases in the analysis group were treated with argatroban anticoagulation,aspirin combined with clopidogrel for antiplatelet aggregation.Results After treatment,the effectiveness of 92.11%in the analysis group was higher than 68.42%in the comparison group,and the difference was statistically significant(χ^(2)=6.728,P=0.009).Before treatment,the neurological deficit scores of the two groups of patients were compared,and the difference was not statistically significant(t=0.041,P=0.967).After treatment,the scores of neurological deficits in the analysis group were lower than those in the comparison group,and the difference was statistically significant(t=21.863,P<0.001).Before treatment,the living ability scores of the two groups were compared,and the difference was not statistically significant(t=0.042,P=0.967).After treatment,the life ability score of the probing group was lower than that of the comparison group,and the difference was statistically significant(t=4.762,P<0.001).There was no statistically significant difference between the two groups in terms of treatment safety(χ^(2)=0.140,P=0.709).Conclusion Aspirin and clopidogrel combined with argatroban in the treatment of acute cerebral infarction has obvious effect on anti-platelet aggregation and anticoagulation.It can also improve the living ability of patients,improve the status of neurological deficit,and reduce the disability rate.