氟哌噻吨美利曲辛联合阿普唑仑治疗冠状动脉粥样硬化性心脏病PCI术后合并抑郁的效果研究

Study on the Effect of Flupentixol and Melitrazin Combined with Alprazolam in the Treatment of Coronary Atherosclerotic Heart Disease with Depression after PCI

目的探讨氟哌噻吨美利曲辛联合阿普唑仑治疗冠状动脉粥样硬化性心脏病(冠心病)经皮冠状动脉介入术(PCI)后合并抑郁的效果。方法78例研究对象均为方便选取2018年6月—2020年5月菏泽市立医院收治的冠心病PCI术后并抑郁症患者,按照随机数表法将其划分为两组。两组PCI术后均采取常规治疗,对照组39例应用阿普唑仑治疗,研究组39例在此基础上联合氟哌噻吨美利曲辛治疗。比较两组治疗前后抑郁情况[汉密尔顿抑郁量表(HAMD)、睡眠质量[匹兹堡睡眠质量指数(PSQI)]、生活质量[生活质量测定量表(QLQ-C30)],以及心血管不良事件与药物不良反应情况。结果治疗后,研究组HAMD评分(9.23±0.54)分较对照组(15.65±0.98)分低,差异有统计学意义(t=35.832,P<0.05),PSQI量表评分(32.52±4.78)分较对照组(46.66±3.70)分低,差异有统计学意义(t=14.609,P<0.05),QLQ-C30量表中角色功能评分(79.65±6.05)分、认知功能评分(79.65±6.52)分、躯体功能评分(67.52±6.02)分、社会功能评分(69.54±5.02)分、情绪功能评分(56.85±4.85)分较对照组(75.52±6.02)分、(75.00±5.03)分、(62.45±5.68)分、(62.45±4.85)分、(50.65±3.78)分高,差异有统计学意义(t=3.022、3.526、3.825、6.343、6.297,P<0.05)。随访1年时间,研究组室性早搏、室性心动过速与心肌梗死的发生率为5.13%、5.13%、0.00%均较对照组低(23.08%、23.08%、15.38%),差异有统计学意义(P<0.05)。两组不良反应发生率均为10.26%,差异无统计学意义(P>0.05)。结论氟哌噻吨美利曲辛联合阿普唑仑治疗冠心病PCI术后合并抑郁具有显著的效果,适于临床推广。

Objective To investigate the effect of Flupentixol melitracen combined with alprazolam in the treatment of depression after coronary heart disease PCI.Methods The 78 study subjects were all patients with depression after PCI and were admitted to Heze Municipal Hospital were selected conveniently from June 2018 to May 2020.They were divided into two groups according to a random number table.Both groups were treated with conventional treatment after PCI,39 cases in the control group were treated with alprazolam,and 39 cases in the study group were treated with flupentixol and melitroxine on this basis.Compared the two groups of depression before and after treatment[Hamilton depression scale(HAMD),sleep quality[Pittsburgh sleep quality Index(PSQI)],quality of life[quality of life measurement Scale(QLQ-C30)],as well as cardiovascular adverse events and adverse drug reactions.Results After treatment,the HAMD score of the study group(9.23±0.54)points was lower than that of the control group(15.65±0.98)points.The difference was statistically significant(t=35.832,P<0.05),and the PSQI scale score(32.52±4.78)points was lower than that of the control group(46.66±3.70)points.The difference was statistically significant(t=14.609,P<0.05).QLQ-C30 Role function score(79.65±6.05)points,cognitive function score(79.65±6.52)points,physical function score(67.52±6.02)points,social function score(69.54±5.02)points,the emotional function score(56.85±4.85)points was higher than that of the control group(75.52±6.02)points,(75.00±5.03)points,(62.45±5.68)points,(62.45±4.85)points,(50.65±3.78)points.The difference was statistically significant(t=3.022,3.526,3.825,6.343,6.297,P<0.05).The incidence of premature ventricular beats,ventricular tachycardia and myocardial infarction in the study group was 5.13%,5.13%and 0.00%lower than that in the control group(23.08%,23.08%and 15.38%).The difference was statistically significant(P<0.05).The incidence of adverse reactions in both groups was 10.26%,and the difference was not statistically significant(P>0.05).Conclusion Flupentixol melitracen combined with alprazolam has a significant effect in the treatment of depression after PCI.