埃索美拉唑与奥美拉唑治疗胃溃疡的效果研究

Study on the Effect of Esomeprazole and Omeprazole in the Treatment of Gastric Ulcer

目的对比分析利用埃索美拉唑及奥美拉唑对胃溃疡患者治疗产生的应用效果。方法方便选取2018年11月—2019年11月该院收治的90例胃溃疡患者作为研究对象,采取单双号的方式进行分组,将随机抽中单号的患者设定为研究组(n=45),该组患者接受埃索美拉唑联合阿莫西林及克拉霉素治疗,将抽中双号的患者设定为对比组(n=45),该组患者接受奥美拉唑联合阿莫西林及克拉霉素治疗,针对两组研究对象临床治疗效果进行对比研究。结果经过治疗,研究组症状积分(1.08±0.33)分、各项血清炎性因子含量[(6.48±1.02)μg/mL、(4.54±0.65)mg/L]均明显较对比组(2.68±0.46)分、[(9.86±1.14)μg/mL、(7.28±0.92)mg/L]更低,差异有统计学意义(t=18.959、14.822、16.317,P<0.05);幽门螺杆菌根除率95.56%显著高于对比组66.67%,差异有统计学意义(χ^(2)=12.256,P<0.05)。治疗后,研究组精神健康为(92.58±1.19)分,生理功能为(92.30±1.48)分,总体健康为(92.06±3.22)分,情感职能为(92.54±1.08)分,对比组患者精神健康、生理功能、总体健康以及情感职能分别为(83.59±3.48)分、(83.20±4.09)分、(83.41±2.16)分、(83.49±2.51)分,两组比较差异有统计学意义(t=16.397、14.035、14.965、22.218,P<0.05)。结论在对胃溃疡患者实施临床治疗时,运用埃索美拉唑进行治疗产生的治疗效果更加突出,值得进一步深入研究。

Objective To compare and analyze the application effect of esomeprazole and omeprazole in the treatment of patients with gastric ulcer.Methods 90 patients with gastric ulcer treated in the hospital from November 2018 to November 2019 were conveniently selected as the research objects,and the patients with single and double numbers were grouped.The patients with single and double numbers were randomly selected as the study group(n=45).The patients in this group were treated with esomeprazole combined with amoxicillin and clarithromycin,and the patients with double numbers were selected as the control group(n=45),The patients in this group were treated with omeprazole combined with amoxicillin and clarithromycin.The clinical therapeutic effects of the two groups were compared.Results After treatment,the study group's symptom score(1.08±0.33)points,the serum inflammatory factor content[(6.48±1.02)μg/mL,(4.54±0.65)mg/L]were significantly higher than the control group(2.68±0.46)points,[(9.86±1.14)μg/mL and(7.28±0.92)mg/L]were lower,and the difference was statistically significant(t=18.959,14.822,16.317,P<0.05).The eradication rate of Helicobacter pylori was 95.56%significantly higher than that of the control group,66.67%,and the difference was statistically significant(χ^(2)=12.256,P<0.05).After treatment,the study group's mental health score was(92.58±1.19)points,the physiological function score was(92.30±1.48)points,the overall health score was(92.06±3.22)points,and the emotional function score was(92.54±1.08)points.The comparison group patients'mental health physiological function,general health,and emotional function were(83.59±3.48)points,(83.20±4.09)points,(83.41±2.16)points,(83.49±2.51)points,respectively,the difference between the two groups was statistically significant(t=16.397,14.035,14.965,22.218,P<0.05).Conclusion In the clinical treatment of patients with gastric ulcer,the effect of esomeprazole is more prominent,which is worthy of further study.