PAI-1基因多态性与脓毒血症易感性的关系

Relationship of PAI-1 gene polymorphism and sepsis susceptibility

目的探讨血浆纤溶酶原激活物抑制剂1(PAI-1)基因多态性与脓毒血症易感性的关系。方法收集97例脓毒血症患者(脓毒血症组)和99例感染性疾病患者(感染组)临床和实验室资料,检测PAI-1基因多态性,采用多因素logistic回归分析脓毒血症发生的影响因素。结果脓毒血症组患者CRP、降钙素原(PCT)、TNF-α、IL-1β、IL-6、IL-10及IL-18水平均高于感染组(P<0.05),PAI-14G/4G基因型比例和4G基因频率高于感染组(P<0.05)。多因素logistic回归分析显示,高水平的CRP、PCT、TNF-α、IL-1β、IL-6、IL-10和IL-18以及PAI-14G/4G基因型是脓毒血症发生的独立危险因素(P<0.05)。PAI-14G/4G基因型患者CRP、PCT及TNF-α水平高于5G/5G基因型患者(P<0.05)。结论PAI-1基因多态性与脓毒血症易感性密切相关,PAI-14G/4G基因型患者更容易发生脓毒血症。

Objective To investigate the relationship of plasminogen activator inhibitor 1(PAI-1)gene polymorphism and sepsis susceptibility.Methods The clinical data and laboratory indexes were collected in 97 patients with sepsis(group A)and 99 patients with infectious diseases(group B).The PAI-1 gene polymorphism was analyzed.The influencing factors for sepsis were analyzed by multivariate logistic regression.Results The levels of CRP,procalcitonin(PCT),TNF-α,IL-1β,IL-6,IL-10 and IL-18,the proportion of PAI-14 G/4 G and the gene frequency of 4 G were higher in group A than those in group B(P<0.05).Multivariate logistic regression analysis showed that higher levels of CRP,PCT,TNF-α,IL-1β,IL-6,IL-10 and IL-18 and 4 G/4 G genotype were the risk factors for sepsis(P<0.05).The levels of CRP,PCT and TNF-αwere higher in the patients with PAI-14 G/4 G genotype than those in the patients with 5 G/5 G genotype(P<0.05).ConclusionPAI-1 gene polymorphism is closely related to the susceptibility to sepsis.The patients with PAI-14 G/4 G genotype are more likely to develop sepsis.