代谢组学在医学蠕虫研究中的应用

Application of metabolomics in research of medical helminths

代谢组学是继基因组学、转录组学和蛋白质组学之后迅速发展起来的一种新兴组学,由于其独特的优势,在疾病早期诊断、药物靶点发现及动植物代谢研究等各个领域中均有应用.如今在寄生虫研究领域中的应用也逐渐增多,主要集中于寄生虫宿主的代谢研究、寄生虫病诊断生物标志物的筛选以及揭示寄生虫病治疗药物的作用机制等方面.为探究寄生虫与宿主相互作用、寄生虫病诊疗等方面提供了新的思路,本文通过对代谢组学及其研究方法、代谢组学在医学蠕虫研究中的应用进展进行综述,以期为其在寄生虫研究领域的广泛应用提供参考。

Metabolomics is a new type of omics that rapidly developed after genomics,transcriptomics and proteomics.Because of its unique advantages,metabolomics has been applied in early diagnosis of diseases,discovery of drug targets,and for understanding animal and plant metabolisms.Metabolomics has been increasingly using in studies of parasites,focusing on parasites*metabolism,screening diagnostic biomarkers and revealing mechanism of drug actions,to provide new ideas for exploring parasite-host interaction,and for further understanding of diagnosis and treatment of parasitic diseases.In this review,we summarize metabolomics associated research methodologies,and advances of their applications in studies of medical helminths,to provide reference for wider application of metabolomics in parasitology research.