晚期糖基化终末产物对骨组织生物力学影响的研究进展

Progress in Advanced Glycation End-Products Effects on Biomechanics of Bone Tissues

晚期糖基化终末产物(advanced glycation end-products,AGEs)是大分子物质的游离氨基与还原糖之间发生的非酶促反应产物。AGEs在骨组织中积聚会通过与骨组织细胞表面受体的结合改变骨组织细胞活性及功能,引起骨重建过程异常。AGEs积聚还会改变骨胶原原有结构及矿物质沉积,影响骨组织的微观力学性能,造成骨强度及韧性的降低,增加骨折风险,导致骨疾病的发生,危害人体健康。概述AGEs的产生原因及检测方法,并从微观和宏观层面综述AGEs在生物体骨组织内积聚对骨生物力学影响的研究进展,为临床上对骨疾病的早期诊断与治疗提供参考。

Advanced glycation end-products(AGEs)are the products of non-enzymatic reactions between free amino groups of macromolecules and reducing sugars.AGEs accumulation in bone tissues changes the activity and function of bone cells by binding to their surface receptors,causing abnormalities in the process of bone remodeling.AGEs accumulation can also change the original structure and mineral deposition of bone collagen,affect the micro-mechanical properties of bone tissues,and further reduce bone strength and toughness,increase the bone fracture risk,which will lead to bone diseases and do great harm to human health.This article summarized the causes of AGEs and their detection methods,and reviewed previous studies about the effects of AGEs accumulation on bone biomechanics at micro and macro levels,so as to provide references for the early diagnosis and treatment of bone diseases in clinic.