^(18)F-FDG PET/CT在32例结直肠癌肝转移瘤动脉化疗栓塞疗效评价中的应用价值

Application value of ^(18)F-FDG PET/CT in therapeutic evaluation of transcatheter arterial chemoembolization of 32 patients with hepatic metastases of colorectal cancer

[目的]探讨^(18)F-FDG PET/CT在结直肠癌肝转移瘤动脉化疗栓塞(TACE)疗效评价中的应用价值.[方法]选择32例结直肠癌伴肝转移瘤患者,于TACE治疗前及治疗后行MRI扫描及^(18)F-FDG PET/CT扫描,测量治疗前、后病灶中心及病灶边缘的SUVmax值,取病灶中心及边缘部的SUVmax平均值,再计算SUVmax平均值的变化值(ΔSUVmax),按照PET-CT实体瘤疗效评价标准2009进行疗效评价.[结果]32例肝转移瘤可测实体瘤共126个,其中MRI扫描判读76个病灶为治疗有效,50个病灶为治疗无效;PET/CT扫描判读104个病灶为治疗有效,22个病灶为治疗无效;相比较差异具有统计学意义(P=0.006).[结论]^(18)F-FDG PET/CT较MRI可更好地反映结直肠癌肝转移瘤TACE术后的疗效.

OBJECTIVE To explore the application value of ^(18)F-FDG PET/CT in therapeutic evaluation of transcatheter arterial chemoembolization(TACE)in hepatic metastases of colorectal cancer.METHODS A total of 32 patients with hepatic metastases of colorectal cancer were selected.Before and after the treatment of TACE,MRI and ^(18)F-FDG PET/CT scan were performed to measure the SUVmax values of the center and edge of the lesions,the mean value of SUVmax of the center and edge of lesions was used to calculate the variation of the mean value of SUVmax(ΔSUVmax),and the curative effect was evaluated according to the PET/CT therapeutic evaluation criteria in solid tumors 2009.RESULTS A total of 126 solid tumors were detected in 32 cases of hepatic metastases,among which 76 lesions were confirmed as effective and 50 lesions as ineffective by MRI scanning,while 104 lesions were identified as effective and 22 lesions as ineffective by PET/CT scanning.The difference was statistically significant(P=0.006).CONCLUSION ^(18)F-FDG PET/CT could better reflect the therapeutic effect of TACE for hepatic metastases of colorectal cancer as compared with MRI.