Whipple手术和开腹Whipple手术用于壶腹周围癌患者的临床效果分析

Analysis of the Clinical Effect of Whipple Operation and Open Whipple Operation in Patients with Periampullary Carcinoma

目的分析胰腺十二指肠切除术(Whipple手术)和开腹Whipple手术用于壶腹周围癌患者的临床效果。方法选取2018年1月2020年3月该院收治的壶腹周围癌患者50例进行研究,采用抽签法随机分组,分为参照组25例与研究组25例,参照组实施传统开腹Whipple手术治疗,研究组实施腹腔镜Whipple手术,对比治疗效果。结果对于手术时间与术中出血量,研究组(51.86±5.45)min、(311.73±120.94)mL更优,差异有统计学意义(t=11.428、3.388,P<0.05);研究组患者的胃肠功能恢复时间(13.85±3.67)h、住院时间(4.56±1.34)d,参照组胃肠功能恢复时间(26.09±4.43)h,住院时间(6.17±1.45)d,差异有统计学意义(t=10.638、4.077,P<0.05);对于并发症发生率,研究组4.00%更优,差异有统计学意义(χ^(2)=4.878,P<0.05);对比治疗后的生活质量评分,研究组更高,与参照组比较,差异有统计学意义(t=5.840,P<0.05)。结论壶腹周围癌者采用腹腔镜Whipple手术治疗,术中出血量少,促进胃肠道功能恢复,缩短治疗进程,并发症发病率低,安全性高,具有显著治疗效果,可广泛应用于临床。

Objective To analyze the clinical effects of pancreaticoduodenectomy(Whipple surgery)and open Whipple surgery for patients with periampullary carcinoma.Methods From Janruary 2018 to March 2020,a total of 50 patients with periampullary carcinoma were selected From the hospital for the study.They were randomly grouped by lottery and divided into a reference group of 25 cases and a study group of 25 cases,the reference group performed traditional open Whipple surgery,and the research group performed laparoscopic Whipple surgery to compare the therapeutic effects.Results For the operation time and intraoperative blood loss,the study group(51.86±5.45)min and(311.73±120.94)mL were better,and the difference was statistically significant(t=11.428,3.388,P<0.05);qastrointestinal function recovery time was(13.85±3.67)h,hospitalization time(4.56±1.34)d,reference group gastrointestinal function recovery time(26.09±4.43)h,hospitalization time(6.17±1.45)d,the difference was statistically significant(t=10.638,4.077,P<0.05);for the incidence of complications,the study group 4.00%was better,and the difference was statistically significant(χ^(2)=4.878,P<0.05);compared with the quality of life score after treatment,the study group was higher,compared with the reference group,the difference was statistically significant(t=5.840,P<0.05).Conclusion Patients with periampullary carcinoma are treated with laparoscopic Whipple surgery,which has less blood loss during the operation,promotes the recovery of gastrointestinal function,shortens the treatment process,reduces the incidence of resection complications,has high safety,and has significant therapeutic effects.It can be widely used in clinic.