临床采用阿立哌唑治疗女性精神分裂症的症状转归情况分析

Analysis of the Symptoms and Outcome of Aripiprazole in the Treatment of Female Schizophrenia

目的探讨临床采用阿立哌唑治疗女性精神分裂症的症状转归情况。方法将该院2019年1月—2020年1月80例女性精神分裂症患者,数字表随机法分为两组。对照组给予利培酮治疗,研究组实施阿立哌唑治疗。比较两组治疗前和治疗后阳性和阴性症状量表总分和各因子评分、治疗总有效率和不良反应发生率。结果两组的阳性和阴性症状量表总分和各因子评分显著低于治疗前。研究组治疗后阳性和阴性症状量表总分、阳性评分、阴性评分、病理评分分别为(55.23±3.21)分、(12.34±2.35)分、(15.21±2.21)分、(22.19±2.32)分,与对照组比较差异无统计学意义(P>0.05)。研究组治疗总有效率(97.50%)和对照组(95.00%)差异无统计学意义(χ^(2)=0.000,P=1.000)。研究组的月经周期改变、锥体外系不良反应和体质量增加等不良反应总的发生率为12.50%,显著低于对照组的37.50%,差异有统计学意义(χ^(2)=6.667,P=0.010)。结论临床采用阿立哌唑治疗女性精神分裂症的效果确切,可有效改善患者的病情,且安全性更高。

Objective To investigate the clinical use of aripiprazole in the treatment of female schizophrenia symptoms.Methods From January 2019 to January 2020,80 female patients with schizophrenia in the hospital were randomly divided into two groups using a digital table.The control group was given risperidone treatment,and the study group was given aripiprazole treatment.The total scores of the positive and negative symptom scales and the scores of each factor,the total effective rate of treatment and the incidence of adverse reactions were compared between the two groups before and after treatment.Results The total scores of the positive and negative symptom scales and the scores of each factor of the two groups were significantly lower than before treatment,the total score,positive score,negative score,and pathology score of the study group after treatment were(55.23±3.21)points,(12.34±2.35)points,(15.21±2.21)points,(22.19±2.32)points,Compared with the control group,the difference was not statistically significantand(P>0.05).There was no statistically significant difference between the study group's total effective rate(97.50%)and the control group(95.00%)(χ^(2)=0.000,P=1.000).The total incidence of side effects such as menstrual cycle changes,extrapyramidal adverse reactions and body mass gain in the study group was 12.50%,which was statistically significantly lower than 37.50%in the control group,the difference was statistically significantand(χ^(2)=6.667,P=0.010).Conclusion The clinical use of aripiprazole in the treatment of female schizophrenia has a definite effect,can effectively improve the patient's condition,and has higher safety.