地西他滨联合预激方案治疗急性髓系白血病的临床有效性分析

Clinical Effectiveness Analysis of Decitabine Combined with Preexcitation in the Treatment of Acute Myeloid Leukemia

目的分析地西他滨+预激方案对急性髓系白血病的有效性。方法选取2020年1月—2021年1月院内治疗的64例急性髓系白血病者为研究对象,预激方案治疗者32例为单一组,地西他滨+预激方案治疗者32例为综合组,观察急性髓系白血病者治疗有效性。结果综合组治疗有效性为90.63%,单一组治疗有效性为68.75%,综合组有效性更高,差异有统计学意义(χ^(2)=4.730,P=0.030)。治疗后,综合组的肺部感染、肝肾损伤、血小板减少发生率为6.25%、9.38%、15.63%,单一组的肺部感染、肝肾损伤、血小板减少发生率为25.00%、31.25%、37.50%,综合组不良反应更少,差异有统计学意义(χ^(2)=4.267、4.730、3.925,P=0.039,0.030,0.048)。综合组对化疗舒适度、化疗有效性满意度为81.25%、87.50%,对化疗时效性、化疗安全性满意度为90.63%、84.38%;单一组对化疗舒适度、化疗有效性满意度为53.13%、65.63%,对化疗时效性、化疗安全性满意度为65.63%、59.38%,综合组治疗满意度更高,差异有统计学意义(χ^(2)=5.741、4.267、5.851、4.947,P=0.017、0.039、0.016、0.026)。结论地西他滨+预激方案有效性高,可使急性髓系白血病临床缓解率提升,同时能减少急性髓系白血病者治疗不良反应,让急性髓系白血病者保持高满意度。

Objective To analyse the efficacy of descitabine+preexcitation regimen in the treatment of acute myeloid leukemia.Methods Selected 64 Patients with acute myeloid leukemia treated in the hospital as research objects from January 2020 to January 2021,all of whom were informed about the implementation of the study,32 patients treated with pre-excitation regimen were single group,32 patients treated with decitabine+pre-excitation regimen were complex group.After clinical treatment,the effectiveness of treatment in patients with acute myeloid leukemia was observed.Results The efficacy of the complex group was 90.63%,and that of the single group was 68.75%.The efficacy of the complex group was higher,and the difference was statistically significant(χ^(2)=4.730,P=0.030).After treatment,the incidence rates of lung infection,liver and kidney injury and thrombocytopenia in the complex group were 6.25%,9.38%and 15.63%,while the incidence rates of lung infection,liver and kidney injury and thrombocytopenia in the single group were 25.00%,31.25%and 37.50%,and there were few adverse reactions in the complex group.The difference was statistically significant(χ^(2)=4.267,4.730,3.925,P=0.039,0.030,0.048).In the complex group,the degree of comfort and effectiveness of chemotherapy was 81.25%and 87.50%,and the degree of effectiveness and safety of chemotherapy was 90.63%and 84.38%.The satisfaction degree of comfort and effectiveness of chemotherapy in single group was 53.13%and 65.63%,while the satisfaction degree of timeliness and safety of chemotherapy was 65.63%and 59.38%.The satisfaction degree of complex group was higher,and the difference was statistically significant(χ^(2)=5.741,4.267,5.851,4.947,P=0.017,0.039,0.016,0.026).Conclusion Descitabine+preexcitation regimen is highly effective,which can improve the clinical remission rate of AML,reduce the adverse reactions of treatment in AML patients,and maintain high satisfaction in AML patients.