神经内分泌肿瘤基础与转化研究进展

Advances in basic and translational research in neuroendocrine neoplasms

随着各种诊断技术的不断发展和人们生活水平的提高,神经内分泌肿瘤的检出率不断增加,越来越受到人们的重视,神经内分泌肿瘤的临床研究进展显著,治疗手段丰富。但是,由于神经内分泌肿瘤的异质性,复发转移依然是困扰临床医生的难题,疗效仍有待提高,亟需对其生物学行为展开深入研究。近年来,随着分子生物学的发展,神经内分泌肿瘤的基础与转化研究均取得了一定进展。本文围绕神经内分泌肿瘤的多组学(体细胞拷贝数变异、基因组学、转录组学等)、肿瘤微环境(免疫微环境、肿瘤微血管、肿瘤相关成纤维细胞等)、临床前研究模型构建(细胞系、类器官、人源性异种移植模型、基因工程小鼠)等前沿热点进行综述,并对具有临床转化意义的部分进行阐述。

With the development of diagnostic techniques and the improvement of people's living standards,the detection rate of neuroendocrine tumor has been increasing and people are paying more and more attention to it.With multiple treatment modalities,the clinical research progress of neuroendocrine tumor is remarkable.However,due to the tumor heterogeneity,metastasis and recurrence of neuroendocrine tumor remains a difficult problem for clinicians.The efficacy of neuroendocrine tumor still needs to be improved.Therefore,the biological behavior of neuroendocrine tumor needs to be further studied.In recent years,with the development of molecular biology,the basic and transformation research of neuroendocrine tumor has made some progress.In this paper,we focus on the hot topics of neuroendocrine tumor,such as multiomics(copy number variation,genomics,transcriptomics),tumor microenvironment(immune microenvironment,tumor microvasculature,tumor-associated fibroblasts,etc.),preclinical research model construction(cell lines,organoids,patient derived xenograft models,genetically engineered mice),etc.Specifically,the related clinical transformation significance will be elaborated.