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IVF/ICSI-ET取卵周期因素与不同移植次数结局的相关性分析 被引量:1

Correlation between oocyte retrieval cycle-related factors and outcome of different embryo transfer times in patients with IVF/ICSI-ET
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摘要 目的分析长方案体外受精/卵细胞浆内单精子注射-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)患者的取卵周期特点对移植次数及结局的影响。方法回顾性分析780例长方案IVF/ICSI-ET患者的临床资料,根据患者的移植次数分为移植1次、移植2次、移植≥3次,分别比较不同移植次数活产组、无活产组患者间取卵周期特点差异。结果移植1次活产者与无活产者比较,前者取卵周期的年龄、基础卵泡刺激素(follicle-stimulating hormone,FSH)水平、基础FSH/黄体生成素(luteinizing hormone,LH)比值更低,促性腺激素(Gonadotropin,Gn)总量、Gn启动剂量更低,获卵个数、MⅡ卵数、优胚数等更高,差异均具有统计学意义(P<0.05);Logistic回归分析显示:优胚数是移植1次结局的影响因素。取卵周期的年龄、基础FSH、获卵数等在移植2次者、≥3次者的活产组、无活产组间均无差异性(P>0.05)。结论长方案IVF/ICSI-ET患者取卵周期优胚数与第1次移植的活产率有关,而取卵周期因素可能与移植次数2次及以上的活产无关。 Objective To analyze the influence of oocyte retrieval cycle-related factors on the outcome of different embryo transfer times in patients with long protocol in vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET).Methods The clinical data of 780 patients with long protocol IVF/ICSI-ET were analyzed retrospectively.Oocyte retrieval cycle-related factors were compared between the live-birth group and the non-live-birth group in patients on the first,second,and third(or more)embryo transfers.Results For patients on the first embryo transfer,the live-birth group had a significantly younger age,a significantly lower basal follicle-stimulating hormone(FSH)level,a significantly lower basal FSH to luteinizing hormone ratio,significantly lower starting and total doses of gonadotropin,and significantly higher numbers of retrieved oocytes,metaphase II oocytes,and good quality embryos in the oocyte retrieval cycle than the non-live-birth group(all P<0.05).The logistic regression analysis showed that the number of good quality embryos was the influencing factor for outcome on the first embryo transfer.There were no significant differences in age,basal FSH,and the number of retrieved oocytes between the live-birth group and the non-live-birth group on the second transfer or on the third(or more)transfer(all P>0.05).Conclusion In patients with long protocol IVF/ICSI-ET,live birth can be affected by the number of good quality embryos in the oocyte retrieval cycle on the first embryo transfer,but may be not associated with the oocyte retrieval cycle-related factors on the second or more embryo transfer.
作者 刘尧芳 文露 付正 陈绍威 王芳 黄桂英 LIU Yao-fang;WEN Lu;FU Zheng;CHEN Shao-wei;WANG Fang;HUANG Gui-ying(Department of Reproductive Technology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处 《西南医科大学学报》 2021年第6期644-649,共6页 Journal of Southwest Medical University
基金 西南医科大附院博士科研启动基金项目(10984)。
关键词 体外受精/卵细胞浆内单精子注射-胚胎移植 移植次数 活产 In vitro fertilization/intracytoplasmic sperm injection and embryo transfer Embryo transfer times Live birth
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