韩雪治疗急性期大叶性肺炎用药规律研究

Study on Medication Regularity of HAN Xue in Treatment of Lobar Pneumonia in Acute Stage

目的:分析韩雪治疗急性期大叶性肺炎的用药规律。方法:收集2019年3月至2020年2月韩雪在郑州大学附属儿童医院中医科病房诊治的急性期大叶性肺炎患儿的中药处方,应用频数分析、因子分析、聚类分析等方法进行挖掘整理,分析组方用药规律。结果:共收集处方301首,涉及68味中药,其中使用频次>20次的药物有33味,以解表药、清热药、化痰止咳平喘药为主,核心处方药物为:蜜麻黄、炒苦杏仁、石膏、甘草、芦根、桃仁、薏苡仁、法半夏、桔梗、瓜蒌、黄连、浙贝母、鱼腥草,常用配伍药物有9组。结论:韩雪治疗急性期大叶性肺炎以清热涤痰、化湿开结、活血排脓为基本治则,临证把握病机,随证加减。

Objective:To analyze the medication regularity of HAN Xue in the treatment of lobar pneumonia in the acute stage.Methods:The prescriptions of traditional Chinese medicine(TCM)for children with acute lobar pneumonia diagnosed and treated by HAN Xue in the TCM ward of Children’s Hospital Affiliated to Zhengzhou University from March 2019 to February 2020 were collected,mined and sorted out by frequency analysis,factor analysis,cluster analysis and other methods to analyze the regularity of prescription and medication.Results:Total 301 prescriptions were collected involving 68 Chinese medicinal herbs.Among them,33 herbs were used more than 20 times,mainly including medicinals for relieving exterior syndrome,medicinals for clearing heat and medicinals for resolving phlegm and relieving cough and asthma.The core prescriptions include:Mimahuang(Ephedrae Herba Praeparata Cum Melle),Chaokuxingren(Armeniacae Semen Amarum),Shigao(Gypsum),Gancao(Glycyrrhizae Radix et Rhizoma),Lugen(Phragmitis Rhizoma),Taoren(Persicae Semen),Yiyiren(Coicis Semen),Fabanxia(Pinelliae Rhizoma Praeparatum),Jiegeng(Platycodon Radix),Gualou(Trichosanthis Fructus),Huanglian(Coptidis Rhizoma),Zhebeimu(Fritillariae Thunbergii Bulbus) and Yuxingcao(Houttuyniae Herba). There were 9 groups of commonly used combinations of medicinal pairs. Conclusions:HAN Xue’s treatment of lobar pneumonia in the acute stage is based on clearing heat and removing phlegm,resolving dampness and dissipating mass,activating blood and expelling pus,adding and subtracting medicinals according syndromes by grasping the pathogenesis.