中药复方治疗糖皮质激素性骨质疏松症用药规律分析

Analysis on Medication Regularity of Traditional Chinese Compound Formula inTreatment of Glucocorticoid Induced Osteoporosis

目的:分析近年来在中文期刊发表的中药复方治疗糖皮质激素性骨质疏松症(GIOP)的相关文献,总结其用药规律。方法:通过万方数据知识服务平台、中国知网、维普期刊资源整合服务平台检索治疗GIOP的中药复方,使用古今医案云V1.5.7,SPSS 23.0软件统计及分析GIOP所涉及的中药用药频率,通过聚类分析、关联分析探讨中药复方治疗GIOP的用药规律。结果:通过检索,筛选出中药复方27首,中药78味,用药频次191,平均每剂中药7味。其中得出高频中药10味(频率>10%),从高到低依次为茯苓、山药、熟地黄、当归、山茱萸、淫羊藿、白术、甘草、泽泻、黄芪。以强筋骨、健脾渗湿、补肾阳、滋肾阴、补益肝肾、活血化瘀药最常用,四气以温、平、微温为主,五味以甘辛苦多见,归经多为肾脾肝。聚类统计后本研究得到8类药组,关联度统计后得到2类药组。结论:通过统计分析,治疗GIOP的中药复方以强筋骨、补肝肾、健脾渗湿、活血化瘀为用药规律,从而为临床组方、用药提供数据支撑。

Objective:To analyze the articles using traditional Chinese compound formula for the treatment of glucocorticoid induced osteoporosis(GIOP)published recently in Chinese journals,and to summarize its medication regularity.Methods:Traditional Chinese compound formulas for GIOP were searched on Wanfang Data Knowledge Service Platform,China National Knowledge Internet and Weipu Journal Resource Integration Service Platform.Ancient and Modern Medical Records Cloud V1.5.7 and SPSS 23.0 Software were used to count and analyze the medication frequency of Chinese medicines involved in GIOP.Cluster analysis and correlation analysis were used to explore the medication regularity of traditional Chinese compound formula in the treatment of GIOP.Results:Through search and screening,total 27 traditional Chinese compound formulas were selected,involving 78 Chinese herbal medicines,and the frequency of medication was 191,with an average of 7 Chinese herbal medicines. Among them,there were 10 high-frequency Chinese medicines(frequency>10%),from high to low including:Fuling(Poria),Shanyao(Dioscoreae Rhizoma),Shudihuang(Rehmannia Radix Praeparata),Danggui(Angelicae Sinensis Radix),Shanzhuyu(Corni Fructus),Yinyanghuo(Epimedii Folium),Baizhu(Atractylodes),Gancao(Glycyrrhizae Radix et Rhizoma),Zexie(Alismatis Rhizoma) and Huangqi(Astragali Radix). The most commonly used Chinese medicines were to strengthen the muscles and bones,invigorate spleen and drain dampness,tonify kidney yang,nourish kidney yin,tonify and replenish liver and kidney,and activate blood and resolve stasis. The four qi were mainly warm,neutral,and slight warm. In terms of five flavors,sweet,pungent and bitter were mainly used. Meridians of kidney,spleen and liver were the main channel tropism. After clustering statistics,8 medicinal groups were obtained in this study,and 2 medicinal groups were obtained after correlation statistics. Conclusions:This study summarized its medication regularity,which are strengthen the muscles and bones,replenishing liver and kidney,invigorating spleen and draining dampness,and activating blood and resolving stasis,through statistical analysis of traditional Chinese compound formula in the treatment of GIOP,so as to provide reference for clinical prescriptions and supply data support for clinical medication selection.