拜新同结合拉贝洛尔治疗方案用在早期妊娠并存高血压患者的临床治疗效果和治疗安全性

The Clinical Efficacy and Safety of Baixintong Combined with Labetalol Treatment Regimen in Early Pregnancy Patients with Hypertension

目的研究拜新同结合拉贝洛尔对早期妊娠并存高血压患者的治疗效果。方法选取该院2020年1—10月期间收治的早期妊娠并存高血压患者108例,随机分为研究组和对照组,每组54例,分别采取拉贝洛尔、拜新同+拉贝洛尔治疗,观察并比较两组患者的治疗效果、并发症、心率、血压、NIHSS评分、血清胱抑素(Cys-C)、24 h尿蛋白、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)等凝血指标。结果研究组治疗总有效率(94.44%)显著高于对照组(79.63%),差异有统计学意义(χ^(2)=5.252,P=0.022);研究组并发症总发生率显著低于对照组,差异有统计学意义(P<0.05);研究组治疗后的心率、血压显著低于对照组,差异有统计学意义(P<0.05);研究组治疗后的NIHSS评分、Cys-C、24 h尿蛋白指标均低于对照组,差异有统计学意义(P<0.05);研究组治疗后的TT、APTT、PT等凝血指标显著高于对照组,差异有统计学意义(P<0.05)。结论对早期妊娠并存高血压患者采取拜新同结合拉贝洛尔治疗,能够减少并发症,稳定心率,降低血压,促进神经功能的恢复,强化肾功能,优化凝血指标,安全性较高,治疗效果较好。

Objective To study the therapeutic effect of Bexintong combined with Labetalol on early pregnancy patients with hypertension.Methods A total of 108 early pregnancy patients with hypertension who were admitted to the hospital from January to October 2020 were selected and randomly divided into a study group and a control group,54 cases in each group.Labetalol and Baixintong+Labetalol treatment were taken respectively,observe and compare the treatment effect,complications,heart rate,blood pressure,NIHSS score,serum cystatin(Cys-C),24 h urine protein,thrombin time(TT),and activation thromboplastin time(APTT),prothrombin time(PT)and other blood coagulation indicators of the two groups of patients.Results The total effective rate of treatment in the study group(94.44%)was significantly higher than that of the control group(79.63%),the difference was statistically significant(χ^(2)=5.252,P=0.022);the total incidence of complications in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05);the heart rate and blood pressure of the treatment group were significantly lower than those of the control group,the difference was statistically significant(P<0.05);the NIHSS score,Cys-C and 24 h urine protein indexes of the study group after treatment were all lower than those of the control group,the difference was statistically significant(P<0.05);The coagulation indexes such as TT,APTT,PT were significantly higher than those of the control group,the difference was statistically significant(P<0.05).Conclusion For patients with early pregnancy coexisting hypertension,the treatment of Baixintong combined with Labetalol can reduce complications,stabilize heart rate,lower blood pressure,promote the recovery of nerve function,strengthen renal function,optimize coagulation indicators,and have high safety.The treatment effect is better.