特发性间质性肺炎应用丹红联合乙酰半胱氨酸方案的疾病转归情况分析

Analysis of Disease Outcome of Idiopathic Interstitial Pneumonia with Danhong Combined with Acetylcysteine Regimen

目的分析特发性间质性肺炎应用丹红联合乙酰半胱氨酸方案的疾病转归情况。方法入组该院2017年1月—2020年1月收治的特发性间质性肺炎患者共50例,随机分组,对照组的患者给予常规药物治疗,观察组则在对照组的基础上增加丹红联合乙酰半胱氨酸方案。比较两组湿啰音消失时间、呼吸困难消失时间、干咳症状消失时间、治疗前后患者血清学炎性因子指标、血氧分压、血清Ⅲ型胶原水平、高分辨率CT评分和6 min步行距离、临床治疗总有效率、不良反应。结果观察组湿啰音消失时间(5.45±1.34)d、呼吸困难消失时间(2.21±0.12)d、干咳症状消失时间(10.11±1.20)d短于对照组相应的指标,差异有统计学意义(t=3.246、4.979、4.213,P<0.05);治疗后观察组血清学炎性因子指标的TNF-α(1.56±0.24)ng/mL、hs-CRP(7.21±1.02)mg/L、IL-6(61.21±2.16)pg/mL、血氧分压(87.34±10.72)mmHg、血清Ⅲ型胶原水平(62.75±2.21)ng/mL、高分辨率CT评分(12.34±1.21)分、6 min步行距离(382.75±20.21)m优于对照组改善程度,差异有统计学意义(t=13.954、5.490、99.352、3.966、5.942、17.170、12.709,P<0.05);观察组治疗总有效率96.00%高于对照组68.00%,差异有统计学意义(χ^(2)=4.878,P<0.05)。结论丹红联合乙酰半胱氨酸方案对于特发性间质性肺炎的效果确切,可有效改善患者临床症状,并改善血清学指标,控制肺部炎症和改善患者的血气水平,促进患者运动耐力的提高。

Objective To analyze the disease outcome of idiopathic interstitial pneumonia using Danhong combined with acetylcysteine regimen.Methods A total of 50 patients with idiopathic interstitial pneumonia admitted to the hospital from January 2017 to January 2020 were randomly divided into two groups.Patients in the control group were given conventional drug treatment,while patients in the observation group were given danhong combined acetylcysteine regimen on the basis of the control group.The disappearance time of wet rrals,dyspnea,dry cough symptoms,serum inflammatory factors,blood oxygen partial pressure,serum typeⅢcollagen level,high resolution CT score and 6-minute walking distance,total clinical treatment response rate and adverse reactions were compared between the two groups.Results The disappearance time of wet rales in the observation group(5.45±1.34)d,the disappearance time of dyspnea(2.21±0.12)d,and the disappearance time of dry cough symptoms(10.11±1.20)d were shorter than the corresponding indicators in the control group,the difference was statistically significant(t=3.246,4.979,4.213,P<0.05);after treatment,the serum inflammatory factors of the observation group were TNF-α(1.56±0.24)ng/mL,hs-CRP(7.21±1.02)mg/L,IL-6(61.21±2.16)pg/mL,blood oxygen partial pressure(87.34±10.72)mmHg,serum typeⅢcollagen level(62.75±2.21)ng/mL,high-resolution CT score(12.34±1.21)points,6 min walking distance(382.75±20.21)m were better than the control group in the degree of improvement,the difference was statistically significant(t=13.954,5.490,99.352,3.966,5.942,17.170,12.709,P<0.05);the total effective rate of treatment in the observation group 96.00%was higher than the control group 68.00%,the difference was statistically significant(χ^(2)=4.878,P<0.05).Conclusion The Danhong combined acetylcysteine regimen has a definite effect on idiopathic interstitial pneumonia.It can effectively improve the clinical symptoms of patients,improve serological indicators,control lung inflammation and improve patients’blood gas levels,and promote patients’exercise endurance.