沙库巴曲缬沙坦治疗难治性心衰的效果分析

Analysis of the Effect of Sacubitril and Valsartan in the Treatment of Refractory Heart Failure

目的探讨难治性心衰患者采用沙库巴曲缬沙坦治疗的效果。方法该次研究抽取该院在2018年6月—2019年6月收治的60例难治性心衰患者,通过随机数表法进行分组,分别为观察组和对照组,各30例。对照组通过米力农注射液治疗,观察组通过沙库巴曲缬沙坦治疗,比较两组临床治疗总有效率及左室射血分数(LVEF)、左室舒张末径(LVEDd)、左室短轴缩短率(LVFS)、B型利钠肽(BNP)水平。结果观察组临床治疗总有效率为93.3%(28/30),高于对照组的70.0%(21/30),差异有统计学意义(χ^(2)=5.455,P<0.05)。观察组患者的LVEF、LVEDd、LVFS、BNP水平分别为(41.26±6.12)%、(5.50±0.56)cm、(31.52±4.80)%、(3413.46±526.43)pg/mL,优于对照组患者,差异有统计学意义(t=5.322、2.522、3.658、19.333,P<0.05)。结论难治性心衰患者通过沙库巴曲缬沙坦治疗,治疗效果明显,心功能得到明显改善,值得推广。

Objective To explore of the effect of treatment with sacubitril and valsartan in patients with refractory heart failure.Methods The study selected 60 patients with refractory heart failure admitted to the hospital from June 2018 to June 2019,and grouped them into observation group and control group with 30 cases each by the random number table method.The control group was treated with milrinone injection,and the observation group was treated with sacubitril and valsartan.To compare the total effective rate of clinical treatment and the levels of left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDd),left ventricular short axis shortening rate(LVFS),and B-type natriuretic peptide(BNP)levels between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.3%(28/30),which was higher than that in the control group 70.0%(21/30),and the difference was statistically significant(χ^(2)=5.455,P<0.05).The levels of LVEF,LVEDd,LVFS,and BNP in the observation group were(41.26±6.12)%,(5.50±0.56)cm,(31.52±4.80)%,and(3413.46±526.43)pg/mL,respectively,which were better than those in the control group.The difference were statistically significant(t=5.322,2.522,3.658,19.333,P<0.05).Conclusion The treatment of patients with refractory heart failure with sacubitril and valsartan has obvious therapeutic effect and obvious improvement of cardiac function,which is worthy of promotion.