马来酸依那普利叶酸片对H型高血压冠心病患者PCI治疗后心血管事件发生的影响

Effects of Enalapril Maleate Folic Acid Tablets on Cardiovascular Events in Patients with H-type Hypertension and Coronary Heart Disease after PCI Treatment

目的H型高血压冠心病患者通过经皮冠状动脉介入法(PCI)治疗后,利用马来酸依那普利叶酸片进行用药,对患者的心血管事件的影响效果进行研究分析。方法该次研究中所抽取的病例均来自于该院在2017年1月—2018年1月期间收治的H型高血压冠心病的患者,从中随机抽取出80例作为研究对象,采用随机数表法将其分成40例观察组和40例对照组,所有患者均通过PCI进行治疗,对照组患者利用常规降压药物进行治疗,观察组患者通过马来酸依那普利叶酸片进行治疗,比较两组患者收缩压、舒张压以及治疗不同时间段后的高同型半胱氨酸(Hcy)的浓度以及心血管事件的发生概率。结果观察组患者治疗6个月后、12个月后的心血管发生概率均低于对照组患者,差异有统计学意义(χ^(2)=4.507、6.275,P<0.05);治疗1个月后,两组心血管发生概率比较,差异无统计学意义(χ^(2)=1.622,P>0.05);观察组患者的舒张压以及收缩压分别为(65.6±10.5)、(113.5±16.4)mmHg,对照组患者的舒张压以及收缩压分别为(86.4±14.5)、(140.5±20.8)mmHg,差异有统计学意义(t=7.348、6.447,P<0.05);观察组患者的6个月后、12个月后的Hcy浓度均低于对照组患者,差异有统计学意义(t=3.323、7.551,P<0.05),两组患者治疗1个月后的Hcy比较,差异无统计学意义(t=0.228,P>0.05)。结论H型高血压冠心病患者通过PCI治疗后,服用马来酸依那普利叶酸片,患者的舒张压、收缩压均显著提升,Hcy浓度以及心血管事件的发生率显著降低,值得推广。

Objective After percutaneous coronary intervention(PCI)treatment in patients with H-type hypertension and coronary heart disease,the use of enalapril maleate folic acid tablets for medication,to study and analyze the effect of the patients'cardiovascular events.Methods The cases selected in this study were all from patients with H-type hypertension and coronary heart disease admitted to the hospital from January 2017 to January 2018.80 cases were randomly selected as the research objects,and they were divided into 40 cases in the observation group and 40 cases in the control group by random number table method.All patients were treated by PCI,patients in the control group were treated with conventional antihypertensive drugs,and patients in the observation group were treated with enalapril maleate folic acid tablets.The systolic blood pressure,diastolic blood pressure,the concentration of homocysteine(Hcy)and the probability of cardiovascular events after different periods of treatment were compared between the two groups.Results The incidence of cardiovascular events in the observation group after 6 months and 12 months of treatment were lower than those in the control group,the difference were statistically significant(χ^(2)=4.507,6.275,P<0.05);after 1 month of treatment,the comparison of the incidence of cardiovascular disease between the two groups,the difference was not statistically significant(χ^(2)=1.622,P>0.05);the diastolic blood pressure and systolic blood pressure of the observation group were(65.6±10.5)mmHg and(113.5±16.4)mmHg,respectively.The diastolic blood pressure and systolic blood pressure of the control group were(86.4±14.5)mmHg and(140.5±20.8)mmHg,the difference were statistically significant(t=7.348,6.447,P<0.05);the Hcy concentration of the observation group after 6 months and 12 months were lower than those of the control group,the difference was statistically significant(t=3.323,7.551,P<0.05);comparison of Hcy between the two groups of patients after 1 month of treatment,and the difference was not statistically significant(t=0.228,P>0.05).Conclusion After PCI treatment in patients with H-type hypertension and coronary heart disease,taking enalapril maleate folic acid tablets,the patients'diastolic blood pressure and systolic blood pressure are significantly increased,and the concentration of Hcy and the incidence of cardiovascular events are significantly reduced.It is worthy of promotion.