全胃肠灌洗联合多次血液灌流在抢救急性中毒患者中的应用效果

Application Effects of Total Gastrointestinal Lavage Combined with Multiple Hemoperfusions in Rescue of Patients with Acute Poisoning

目的探讨全胃肠灌洗联合多次血液灌流在抢救急性中毒患者中的应用效果。方法选取2018年12月至2020年12月医院急诊中心收治的52例急性中毒患者,按随机数字表法分为两组,各26例。对照组行传统的一次洗胃和血液灌流治疗,观察组在对照组基础上加用全胃肠灌洗联合多次血液灌流治疗,持续观察至患者出院,比较两组临床疗效、治疗情况。结果观察组治疗总有效率为92.31%,高于对照组的69.23%,差异有统计学意义(P<0.05);观察组盐酸戊乙奎醚注射液、碘解磷定注射液用量分别为(15.12±2.04)mg、(32.85±4.17)g,均少于对照组的(20.39±2.57)mg、(32.85±4.17)g,意识清醒、胆碱酯酶(CHE)恢复至50%及住院时间分别为(25.63±4.12)h、(57.96±7.54)h、(11.25±1.68)d,均短于对照组的(34.57±4.52)h、(68.75±8.69)h、(14.89±2.05)d,差异均有统计学意义(P<0.05)。结论全胃肠灌洗联合多次血液灌流可提高对急性中毒患者的治疗效果,缩短患者清醒、CHE恢复及住院时间,减少盐酸戊乙奎醚注射液等药物用量。

Objective The application effects of total gastrointestinal lavage combined with multiple hemoperfusions in the rescue of patients with acute poisoning were explored.Methods A total of 52 patients with acute poisoning admitted to the emergency center of the hospital from December 2018 to December 2020 were selected and divided into two groups according to the random number table method,with 26 cases in each group.The control group received traditional gastric lavage and hemoperfusion for once,and the observation group received total gastrointestinal lavage combined with multiple hemoperfusions based on the same treatment with the control group,and continued observation was performed until the patients were discharged.The clinical efficacy and treatment status of the two groups were compared.Results The total effective rate of treatment in the observation group was 92.31%,which was higher than 69.23%in the control group,and the difference was statistically significant(P<0.05);The dosages of penehyclidine hydrochloride injection and pralidoxime iodide injection were(15.12±2.04)mg,(32.85±4.17)g,respectively,which were both less than(20.39±2.57)mg and(32.85±4.17)g in the control group,the wakefulness time,time of cholinesterase(CHE)recovered to 50%,and the hospitalization time in the observation group were(25.63±4.12)h,(57.96±7.54)h,(11.25±1.68)d,which were all shorter than(34.57±4.52)h,(68.75±8.69)h,(14.89±2.05)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Total gastrointestinal lavage combined with multiple hemoperfusions can enhance the therapeutic effects of patients with acute poisoning,shorten the patients'wakefulness and CHE recovery time,and reduce the dosage of penehyclidine hydrochloride injection and other drugs.