小五味子汤对咳嗽变异性哮喘患儿气道功能及血清SAA、IFN-γ的影响

Effect of Schisandrae Decoction on Airway Function and Serum SAA and IFN-γfor Children with Cough Variant Asthma

目的:观察咳嗽变异性哮喘患儿使用小五味子汤对气道功能、血清淀粉样蛋白A(SAA)、干扰素γ(IFN-γ)含量影响。方法:选择我院2017年8月~2019年8月收治的咳嗽变异性哮喘患儿96例,随机分为观察组(n=48)和对照组(n=48),其中对照组西药,观察组西药+小五味子汤,两组患儿均实施为期1月治疗。观察治疗后两组患儿临床疗效,对比治疗前后25%肺活量位的最大呼气流量(MEF25)、50%肺活量位的最大呼气流量(MEF50)、75%肺活量位的最大呼气流量(MEF75)、用力肺活量(FVC)、第1s秒用力呼气容积(FEV1)、最大呼气流量(PEF)、血清中嗜酸性粒细胞(EOS)、血清SAA、血清IFN-γ含量,并使用莱塞斯特咳嗽问卷(LCQ)调查其治疗前后生活质量。结果:观察组治疗后临床疗效为85.42%,高于对照组66.67%(P<0.05)。观察组治疗后MEF25、MEF50、MEF75均高于对照组(P<0.05);观察组治疗后FVC、FEV1、PEF均高于对照组(P<0.05);观察组治疗后血清EOS、SAA水平均明显低于对照组(P<0.05),观察组治疗后血清IFN-γ水平明显高于对照组(P<0.05);观察组治疗后LCQ问卷各维度评分均明显高于对照组(P<0.05)。结论:咳嗽变异性哮喘患儿使用中西医联合治疗效果较好,加用小五味子汤后可改善患儿气道功能、肺功能、血清SAA和IFN-γ含量等有关,且在一定程度上提高患儿生活质量。

Objective:To study the effect of Schisandrae Decoction on airway function,serum amyloid protein A(SAA)and interferon gamma(IFN-γ)for children with cough variant asthma.Methods:96 children with cough variant asthma treated in our hospital from August 2017 to August 2019 were randomly divided into an observation group(n=48)and a controlled group(n=48).The controlled group was treated with routine western medicine and the observation group was treated with Schisandrae Decoction on the basis of the controlled group.Both groups were treated for one month.The clinical effects of the two groups were observed before and after treatment,and the maximum expiratory flow(MEF25),maximum expiratory flow(MEF50),maximum expiratory flow(MEF75),FVC,FEV1,maximum expiratory flow(PEF),serum eosinophil(EOS),serum SAA and serum IFN-γin serum were compared before and after treatment.The quality of life before and after treatment was investigated with Lexter cough questionnaire(LCQ).Results:The clinical effect of the observation group after treatment was 85.42%,which was higher than that of the controlled group(66.67%)(P<0.05).After treatment,the levels of MEF25,MEF50 and MEF75 in the observation group were higher than those in the controlled group,and the levels of FVC,FEV1 and PEF in the observation group were higher than those in the controlled group(P<0.05).The levels of serum EOS and SAA in the observation group after treatment were significantly lower than those in the controlled group,and the level of serum IFN-γin the observation group was significantly higher than that in the controlled group(P<0.05).After treatment,the scores of all dimensions of LCQ questionnaire in the observation group were significantly higher than those in the controlled group(P<0.05).Conclusion:Schisandrae Decoction can effectively improve the therapeutic effect of conventional western medicine in children with cough variant asthma,which may be related to the improvement of airway function,pulmonary function,serum SAA and IFN-γ,thus improving the quality of life to some extent.