卵巢恶性生殖细胞肿瘤保生育治疗后影响妊娠的因素分析

Analysis of factors influencing pregnancy after fertility sparing treatment for malignant ovarian germ cell tumors

目的探讨卵巢恶性生殖细胞肿瘤患者接受保留生育功能治疗后的妊娠状况及其影响因素。方法选择2006年12月—2019年3月广西医科大学附属肿瘤医院收治的72例卵巢恶性生殖细胞肿瘤且接受保留生育功能治疗的患者为研究对象,根据治疗后的妊娠情况,将患者分为治疗后妊娠组和未妊娠组,采用logistic回归分析影响妊娠的因素。结果72例患者中妊娠率为66.7%,logistic回归结果显示,是否切除淋巴结、是否楔形切除健侧卵巢、是否切除大网膜是妊娠的独立影响因素(均P<0.05)。结论采用楔形切除健侧卵巢及切除淋巴结、大网膜的恶性生殖细胞肿瘤患者行保留生育功能治疗后妊娠率降低,但该结论尚需进一步论证。

Objective To investigate the pregnancy status of patients with malignant ovarian germ cell tumors(MOGCT)after fertility sparing treatment and its influencing factors.Methods A total of 72 MOGCT patients,who were admitted to the Guangxi Medical University Cancer Hospital and received fertility sparing treatment from December 2006 to March 2019,were selected as the research subjects.According to the pregnancy status after treatment,the patients were divided into pregnancy group and infertility group.The logistic regression was used to analyze the factors influencing pregnancy.Results The pregnancy rate of 72 patients was 66.7%.The logistic regression results showed that lymph node removal,wedge removal of the contralateral ovary,and omentum removal were independent influence factors of pregnancy(all P<0.05).Conclusions The pregnancy rate of MOGCT patients with wedge removal of the contralateral ovary,lymph node removal and omentum removal was reduced after fertility sparing treatment,but the conclusion needs further confirmation.