挑食行为儿童血清维生素ADE水平分析

Analysis of serum vitamin ADE levels in children with picky eating behavior

目的探讨血清维生素A、D、E水平与儿童挑食问题的相关性。方法收集首都儿科研究所附属儿童医院儿童保健门诊2018年12月至2019年11月就诊的2岁以上普食儿童临床资料,包括身高、体重等体格测量数据,采用高效液相色谱法测定儿童血清维生素A、E水平,液相串联质谱法测定血清25-(OH)D水平。入组儿童分为健康对照组和挑食组,所有数据应用SPSS 21软件进行正态性检验、卡方检验和回归分析等处理。结果共纳入儿童109名,其中健康对照组71名,挑食组38例。对照组维生素E水平为(8.51±2.29)mg/L,挑食组儿童维生素E水平为(7.55±1.62)mg/L,差异有统计学意义(P<0.05)。对照组儿童年龄别体重Z评分(WAZ)、年龄别身高Z评分(HAZ)、年龄别体重指数(BMI)Z评分(BAZ)分别为-(0.04±1.17)、(0.18±1.05)、-(0.25±1.24),挑食组儿童的分别为-(0.95±0.99)、-(0.35±0.92)、-(1.14±1.43),差异均有统计学意义(P<0.05)。挑食组儿童血清维生素E水平缺乏和不足的比例高达50.0%,远高于对照组儿童23.9%,差异有统计学意义(P<0.05)。健康组儿童和挑食组儿童血清维生素A低于正常水平比例分别为31.0%、28.9%,血清25-(OH)D低于正常水平的比例分别为68.0%、58.8%,差异均无统计学意义。Logistic回归分析显示,挑食行为对维生素E水平有显著影响(OR=0.773,95%CI:0.606~0.985),对维生素A、25-(OH)D水平没有显著影响(P>0.05)。结论挑食儿童维生素E水平低于健康对照组,缺乏及不足比例高,应关注挑食行为儿童血清维生素E水平及膳食指导。

Objective The aim of this study is to explore the correlation between serum vitamin A、D and E levels and children’s picky eating problem. Methods We collected clinical data of children over 2 years old who were hospitalized in the health care clinic of Capital Institute of including height,weight and other physical measurements.Their serum vitamin A and vitamin E levels were measured by high performance liquid chromatography(HPLC)and serum 25-(OH)D levels were measured by high performance liquid chromatography tandem mass spectrometry(HPLCMS/MS).The children were divided into healthy group and picky eating group.In data analysis,SPSS 21 software was employed to perform test of normality,chi-square test and logistic regression analysis,et al. Results A total of 109 children were included including 71 children in the healthy control group and 38 children in the picky eating group.The vitamin E level of the control group was(8.51±2.29)mg/L,and that of the picky eating group was(7.55±1.62)mg/L,the difference was statistically significant(P<0.05).The weight-for-age Z-scores(WAZ),height-for-age Z-scores(HAZ),BMI-for-age Z-scores(BAZ)were-(0.04±1.17),(0.18±1.05),-(0.25±1.24)respectively,while those of the picky eating group were-(0.95±0.99),-(0.35±0.92),-(1.14±1.43),respectively,with statistical significance(P <0.05).The deficient and insufficient constituent ratio of serum vitamin E in picky eating group was 50.0%,which was much higher than that of control group(23.9%),the difference was statistically significant(P <0.05).The proportions of serum vitamin A below normal level in the two groups were 31.0% and 28.9% and the proportions of serum 25-(OH)D below normal level were 68.0% and 58.8%,respectively.There were no significant differences between the two groups.Binary logistic regression analysis showed thatpicky eating had a significant impact on Vitamin E level(OR=0.773,95% CI:0.606-0.985),there was no significant effect on the level of vitamin A and 25-(OH)D(P >0.05). Conclusion The vitamin E level of picky eating children was lower than that of healthy control group,and the deficient and insufficient ratio were high.Attention should be paid to the serum vitamin E level of children with picky eating behavior and dietary guidance.