高原地区成人幽门螺旋杆菌感染现状及其相关因素

The Status and Relative Factors of Helicobacter pylori Infection among Health Adult Examination Population in the Plateau Region of China

目的:了解高原地区成人幽门螺旋杆菌(Hp)感染情况及在不同海拔地区的分布情况及其影响因素。方法:收集林芝市各县区(海拔2500-3500m)的2381名居住超过1年的常住人群的尿素^(13)C呼气试验检测结果,并对其进行常规健康问卷调查,比较不同海拔地区常住人口Hp感染阳性率。结果:2381例Hp受检者中有1154例检出Hp阳性,阳性率为48.47%。年龄≥50岁、有烟酒习惯、以肉食为主饮食、合并糖尿病、合并高脂血症者、合并高尿酸血症者Hp阳性率均较高(P<0.05)。海拔3500m环境下常住人群Hp阳性率(56.76%)明显高于2500 m海拔和3000 m海拔环境下常住人群(42.34%,48.93%),不同海拔之间有明显的统计学差异(P<0.05)。结论:在林芝市常住人群中Hp感染率约为48.47%,随着海拔的升高,空气中氧分压下降,Hp感染率增高。高龄、有烟酒习惯、饮食以肉食为主、合并糖尿病、高脂血症、高尿酸血症可能与感染Hp相关。

Objective:To investigate the status of Helicobacter pylori(Hp)infection in Linzhi,China and the influencing factors. Methods:A total of 2381 physical examinee lived in Linzhi for more than one year were selected as respondents from Aug 2020 to May 2021,the ^(13)C breath test was used to detect Hp infection,a self-made questionnaire was used to collect general information,and the Hp infection rates among permanent residents in different altitude areas were compared and analyzed. Results:Among these 2381 physicalexaminee,1154 were found to have Hp infection,infection rate was 48.47%. Hp positive rate was higher in those aged over 50 years old,habit of smoking and drinking,mainly had carnivorous diet,with diabetes and hyperlipidemia and hyperuricemia(all P<0.05). The Hp infection rate of permanent residents at 3500 m altitude(56.76%)was significantly higher than that at 2500 m altitude or 3000 m altitude(42.34%,48.93%). Conclusion:The prevalence of Hp infection in Linzhi residents is about 48.47%,which could be associated with age over 50 years old,smoking and alcohol consumption,carnivorous diet,diabetes,hyperlipidemia and hyperuricemia.With the increase of altitude,the oxygen partial pressure in the air decreased,and the Hp infection rate increased.