肩袖肌腱损伤病理机制的研究进展

Research progress in pathological mechanism of rotator cuff injuries

肩袖肌腱损伤是运动系统的常见病,泛指与过劳损伤相关的一类慢性肩袖肌腱疾病,主要临床表现为肩关节疼痛和上肢运动功能障碍,严重影响人们的生活质量和工作能力。炎症反应、胶原基质变性等与肩袖肌腱损伤的发生发展密切相关,但目前对该病的发病机制仍缺乏清楚的认识。笔者从氧化应激、炎性细胞因子及相关信号通路、巨噬细胞、非编码RNA等方面对肩袖肌腱损伤病理机制的研究进展进行综述,为后续肩袖肌腱损伤的研究及治疗提供参考。

The rotator cuff injury is a kind of chronic tendon disease related to overuse injury.The main clinical manifestations of this disease include shoulder pain and dysfunction,which seriously affects people's life quality and work capability.Although previous studies have shown that inflammation and de-generation of collagen matrix are closely related to the occurrence and development of this disease,the pathogenesis of the disease is still unclear.In this study,the authors review the pathologic mechanisms of rotator cuff injuries from aspects of oxidative stress,inflammation,macrophage and non-coding RNA so as to provide a reference for subsequent research and treatment.