抗血管生成治疗影响肿瘤免疫治疗的研究进展

Advances in Effects of Anti-angiogenesis Therapy on Immunotherapy for Tumors

免疫治疗已经被证实是一种有效的肿瘤治疗手段,但应答率一直不理想。研究发现免疫治疗有多种影响因素,其中异常的肿瘤微环境会导致免疫抑制,减弱免疫治疗效果。抗血管生成治疗是一种通过拮抗促血管生成因子来调节肿瘤血管的治疗方式,可以改变肿瘤微环境进而加强自身的免疫刺激作用。临床上已证实抗血管生成治疗联合免疫治疗这一新型联合免疫治疗策略可以有效提高肿瘤治疗水平。本文就抗血管生成治疗对免疫治疗影响的机制展开综述。

Immunotherapy is a treatment for tumor,which has been proven to be effective,but the response rate of immunotherapy is unsatisfied.There are many factors that have influence on immunotherapy.Tumor microenvironment is one of the factors affecting immunotherapy,and abnormal tumor microenvironment will lead to immunosuppression and weaken the effect of immunotherapy.Anti-angiogenesis therapy is a treatment that regulates tumor blood vessels by antagonizing pro-angiogenic factors.It can change the tumor microenvironment,thus improves tumor immunotherapy.It has been clinically proven that anti-angiogenesis therapy combined with immunotherapy can effectively improve the effects of tumor therapy.This article reviews the mechanisms of anti-angiogenesis therapy on immunotherapy.