组织工程技术促进股骨头坏死骨组织再血管化的研究进展

Research progress of tissue engineering technology in promoting revascularization of necrotic femoral bone tissue

目的总结采用组织工程技术促进股骨头坏死(osteonecrosis of the femoral head,ONFH)骨组织再血管化的研究进展。方法广泛查阅近年国内外相关文献,阐明股骨头血管化机制,对组织工程技术在促进ONFH骨组织再血管化中的应用进展进行总结归纳。结果重建或改善股骨头血供是治疗ONFH的关键,目前组织工程研究热点主要基于种子细胞、支架材料以及促血管生成因子三方面,联合3D打印技术和药物递送系统来促进股骨头骨组织再血管化。结论基于组织工程技术的股骨头再血管化策略,有望改善局部血供,延缓甚至逆转ONFH进展。

Objective To summarize the research progress of tissue engineering technology to promote bone tissue revascularization in osteonecrosis of the femoral head(ONFH). Methods The relevant domestic and foreign literature in recent years was extensively reviewed. The mechanism of femoral head vascularization and the application progress of tissue engineering technology in the promotion of ONFH bone tissue revascularization were summarized.Results Rebuilding or improving the blood supply of the femoral head is the key to the treatment of ONFH. Tissue engineering is a hot spot in current research. It mainly focuses on the three elements of seed cells, scaffold materials, and angiogenic growth factors, combined with three-dimensional printing technology and drug delivery systems to promote the revascularization of the femoral bone tissue. Conclusion The strategy of revascularization of the femoral head can improve the local blood supply and delay or even reverse the progression of ONFH disease.