基于机会成本原理的医药经济学评价参照物选择机制研究

The Mechanism of Choice of Comparator for Pharmacoeconomic Evaluation Based on Opportunity Cost Theory

医药经济学评价中参照物的选择会对研究结果产生很大影响,其选择机制存有争议。经济学中机会成本原理认为参照物的设置是为了计算研究物的机会成本,而机会成本是选择放弃其他选项的最大利益,因此参照物选择应该选择全部其他选项。若只选择一个参照物,则应该选择净收益最大者。基于此理论分析,可进一步对参照物的品种和价格的具体选择机制进行分析和界定。

Choice of comparator would impact the result of pharmacoeconomic evaluation significantly and it’s controversial.Based on opportunity cost theory,it is believed that all other choices should be used as comparator,not just one of them since the meaning of comparator was to calculate the opportunity cost of study objective.If only one comparator was used,the one with biggest net benefit should be selected.With this theory,the selecting mechanism of type and price of comparator in pharmacoeconomic evaluation were analyzed and defined.