兔流行性腹胀病病原分离鉴定与防治

Isolation,identification and control of rabbit epidemic abdominal distension

为了有效控制家兔流行性腹胀病的蔓延,结合流行病学调查和实验室鉴别诊断技术,对112例40~90日龄患病兔病样开展病原检测,其中,分离鉴定出大肠埃希菌(Escherichia coli)的有78例,分离鉴定出魏氏梭菌(Clostridium welchii)的有69例。致病性试验表明,这两大分离菌为兔流行性腹胀病的主要致病菌。在3个常发病兔场开展溶菌酶临床防治试验。结果显示,无论是预防试验中的发病率,还是治疗试验中的病死率,溶菌酶处理组均比对照组低50多个百分点,表明溶菌酶对该病的防治效果明显,能有效遏制病情蔓延,可作为当前替代抗生素的首选药物。研究结果为兔流行性腹胀病的防治提供了科学依据。

In order to effectively control the spread of epidemic abdominal distension in rabbits,epidemiological investigation and laboratory differential diagnosis technology were applied in the present study.Pathogen detection was carried out on 112 cases of 40-90-d-old diseased rabbits.Among them,Escherichia coli and Clostridium welchii were isolated and identified from 78 and 69 diseased rabbits,respectively.The pathogenic characteristics test showed that these two species were the main pathogens of epidemic abdominal distension in rabbits.The clinical control trials of lysozyme were carried out in 3 rabbit farms suffering from epidemic abdominal distension.It was shown that either the incidence rate in the prevention trial or the mortality rate in the control trial was lowered by 50 percentage points in the treatment group than that in the control group.The results indicated that lysozyme could prevent and treat the disease,hence effectively curb the spread of the disease.Therefore,it could be used as the substitution of antibiotics.These findings provided scientific basis for the prevention and treatment of rabbit epidemic abdominal distension.