淫羊藿苷对细胞骨架调控作用的研究进展

Research Progress of Icariin in Regulating Cytoskeleton Function

淫羊藿具有补肝肾、强筋骨、祛风湿等功效,近年来其有效活性成分淫羊藿苷的多重药理活性受到广泛关注。现代研究表明细胞骨架功能异常可引发多种疾病,而淫羊藿苷可以通过对细胞骨架发挥修复保护或抑制破坏作用,对细胞功能进行调控。本文综述了淫羊藿苷对不同疾病靶细胞的细胞骨架的调控作用及机制的研究进展,以期为这种具有临床应用潜力的中药单体的开发提供依据。

Epimedium has the effects of nourishing Liver and Kidney,strengthening muscles and bones,as well as expelling wind-dampness.Icariin is the most important active ingredient of epimedium.Its multiple pharmacological activities have been found recently and attracted more attention.Modern researches verify that abnormal cytoskeleton function can cause a variety of diseases,and icariin can regulate cell function by repairing and protecting,or inhibiting and destroying the cytoskeleton.This study reviewed the regulation effects and the mechanisms of icariin on the cytoskeleton of target cells in different diseases,aiming to provide evidence for the clinical development of icariin.