探讨COPD急性加重期患者血清CRP和PCT含量与全身炎症反应程度的相关性

To investigate the correlation between the levels of serum CRP and PCT and the degree of systemic inflammatory response in patients with acute exacerbation of COPD

目的探究慢性阻塞性肺疾病(COPD)急性加重期患者血清C反应蛋白(CRP)、降钙素原(PCT)含量与全身炎症反应程度的相关性。方法选取2015年6月至2018年10月本院收治的60例急性加重期COPD患者作为观察组,同时选取60名健康体检者作为对照组,测定两组血清CRP和PCT含量水平以及观察组全身炎症因子水平,比较两组血清CRP和PCT含量,评估观察组不同血清CRP与PCT水平对应的炎症因子水平。结果观察组血清CRP和PCT含量均显著高于对照组(P<0.05)。与血清CRP、PCT含量水平较高患者比较,水平较低患者炎症因子水平较低,而抗炎因子水平较高,差异具有统计学意义(P<0.05)。结论急性加重期COPD患者,血清CRP与PCT水平出现异常升高,升高越明显则对应的抗炎因子水平越低,而炎症因子水平较高,表明血清CRP和PCT含量与全身炎症反应程度呈正相关。

Objective To investigate the relationship between serum C-reactive protein(CRP)and calcitonin(PCT)content and systemic inflammatory response in patients with chronic obstructive pulmonary disease(COPD)during acute hypertrophy.Methods 60 patients with acute aggravation COPD admitted to our hospital in June 2015 to October 2018 were taken as the observation group,and 60 patients with health examination were taken as the control group,to determine the levels of serum CRP and PCT in the two groups and the levels of systemic inflammatory factors in the observation group.The levels of serum CRP and PCT in the two groups were compared and the corresponding levels of inflammatory factors were evaluated.Results Serum CRP and PCT in the observation group were significantly higher than those in the control group(P<0.05).Compared with the patients with higher serum CRP and PCT levels,the level of inflammation factor was lower in patients with lower levels,and the level of anti-inflammatory factor was higher,and the difference was statistically significant(P<0.05).Conclusion In patients with acute gravity COPD,the serum CRP and PCT levels increased abnormally.The higher the increase,the lower the corresponding anti-inflammatory factor level and the higher the inflammatory factor level,the results showed that serum CRP and PCT levels were positively correlated with systemic inflammatory response.