脑胶质瘤患者微创手术前后血清IL-17 MCP-1 TNF-α的表达及意义

Expression and clinical significance of serum IL-17,MCP-1 and TNF-α in patients with glioma before and after minimally invasive surgery

目的分析脑胶质瘤患者微创手术前后血清IL-17、MCP-1、TNF-α水平的变化,分析各指标水平变化对手术效果的预测价值。方法选取商丘市第三人民医院2015-01—2019-02收治的100例脑胶质瘤患者为观察组,均接受微创手术治疗,另选取50例健康受检者为对照组,均接受血清IL-17、MCP-1、TNF-α水平测定,对比分析各组上述因子水平。结果观察组Ⅰ、Ⅱ、Ⅲ、Ⅳ级脑胶质瘤患者血清IL-17[Ⅰ级(63.28±13.21)ng/L,Ⅱ级(75.45±15.28)ng/L,Ⅲ级(98.58±18.62)ng/L,Ⅳ级(114.27±21.37)ng/L]、TNF-α[Ⅰ级(16.52±2.95)ng/L,Ⅱ级(13.43±3.24)ng/L,Ⅲ级(9.13±2.57)ng/L,Ⅳ级(7.54±2.1)ng/L]水平均高于健康对照组[(34.26±10.19)ng/L、(2.35±1.65)ng/L],MCP-1[(355.69±95.27)pg/mL、(287.42±52.13)pg/mL、(233.62±45.30)pg/mL、(185.24±37.19)pg/mL]水平低于健康对照组[(447.85±96.38)pg/mL],差异有统计学意义(P<0.05);观察组术后2周低级别、高级别患者术后血清IL-17[低级别组(39.56±8.59)ng/L vs(64.23±12.24)ng/L,高级别组(62.23±10.18)ng/L vs(105.41±11.37)ng/L]、TNF-α[低级别组(2.64±1.32)ng/L vs(15.41±3.29)ng/L,高级别组(4.56±2.09)ng/L vs(10.19±2.31)ng/L]水平低于术前1 d,MCP-1[低级别组(437.46±101.27)pg/mL vs(318.59±85.27)pg/mL,高级别组(381.12±70.65)pg/mL vs(206.37±84.24)pg/mL]水平高于术前1 d,差异有统计学意义(P<0.05);观察组中复发及死亡的脑胶质瘤患者血清IL-17、TNF-α水平明显更高,MCP-1水平明显更低(P<0.05)。结论脑胶质瘤患者微创手术前后血清IL-17、MCP-1、TNF-α水平存在明显差异,通过测定上述指标水平有助于判断微创手术效果,评估预后。

Objective To analyze the changes of serum IL-17,McP-1 and TNF-αlevels in glioma patients before and after minimally invasive surgery,and to analyze the value of the changes of each indicator level in determining the surgical effect.Methods One hundred patients with glioma from January 2015 to February 2019 were selected as subjects,all of whom received minimally invasive surgery,and 50 healthy subjects were selected as controls.Serum levels of IL-17,McP-1 and TNF-αwere measured,and the results were analyzed.Results The levels of IL-17 and TNF-αin patients with glioma in the observation group were higher than those in the healthy control group,and the levels of McP-1 were lower than those in the healthy control group(P<0.05).In the observation group,after operation of two weeks,IL-17 and TNF-αlevels were lower and McP-1 levels were higher than those before operation(P<0.05).In the observation group,the levels of IL-17 and TNF-αwere significantly higher and the levels of McP-1 were significantly lower in the recurrent and dead glioma patients(P<0.05).Conclusion Conclusion:There were significant differences in serum IL-17,McP-1 and TNF-αlevels in glioma patients before and after minimally invasive surgery.The measurement of the above indicators can help to determine the effect of minimally invasive surgery and assess the prognosis.