血浆E3泛素连接酶Pellino-1及降钙素原水平对脓毒症早期诊断的价值

The value of plasma E3 ubiquitin ligase Pellino-1 and procalcitonin levels in the early diagnosis of sepsis

【目的】探讨血浆E3泛素连接酶Pellino-1及降钙素原(PCT)水平对脓毒症早期诊断的价值。【方法】收集我院收治的36例脓毒症患者,其中脓毒症组19例、脓毒性休克组17例,随机纳入同期健康体检者15例作为对照组。通过检测患者血浆Pellino-1蛋白浓度和评估序贯器官衰竭评分(SOFA);分析二者间的关系。【结果】血浆Pellino-1浓度在脓毒性休克组高于脓毒症组及对照组(P<0.05);脓毒症患者血浆中Pellino-1水平与SOFA评分呈正相关性(r=0.890,P<0.05)。Pellino-1受试者工作特征(ROC)曲线下面积为0.813;PCT曲线下面积为0.944。【结论】血浆Pellino-1及PCT水平对脓毒症早期诊断均具有参考价值。早期血浆中Pellino-1升高与不良预后相关。

【Objective】To investigate the value of E3 ubiquitin ligase Pellino-1 and procalcitonin(PCT)levels in the early diagnosis of sepsis.【Methods】A total of 36 patients with sepsis admitted to our hospital were enrolled,including 19 patients in the sepsis group and 17 patients in the septic shock group,and 15 healthy people who underwent physical examination during the same period were randomly included as the control group.Plasma Pellino-1 protein concentration and Sequential Organ Failure Score(SOFA)were assessed,and the relationship between them were analyzed.【Results】The plasma Pellino-1 concentration in septic shock group was higher than that in sepsis group and control group(P<0.05);There was a positive correlation between plasma Pellino-1 level and SOFA score in patients with sepsis(r=0.890,P<0.05).The area under Pellino-1 receiver operator characteristic curve was 0.813;The area under the PCT curve was 0.944.【Conclusion】Plasma Pellino-1 and PCT levels have reference value for early diagnosis of sepsis.Early elevation of Pellino-1 in plasma is associated with poor prognosis.