帕立骨化醇与骨化三醇对继发性甲状旁腺功能亢进症的治疗效果分析

Analysis of the Therapeutic Effect of Paricalcitol and Calcitriol on Secondary Hyperparathyroidism

目的对继发性甲状旁腺功能亢进症患者实施帕立骨化醇与骨化三醇联合治疗的临床效果进行分析。方法方便选取该院在2019年10月—2020年12月接收的86例继发性甲状旁腺功能亢进症患者作为评估对象,将患者分为两组,即研究组、对照组(奇偶分组法),各43例,前者对患者实施帕立骨化醇治疗措施,后者实施骨化三醇治疗,将两组患者治疗有各项指标状况及有效情况进行评估。结果治疗后,研究组患者碱性磷酸酶(74.21±2.12)mmol/L、血磷水平(1.28±0.14)mmol/L、全段甲状旁腺激素(213.26±5.12)pg/mL、血钙(2.72±0.36)mmol/L,对照组碱性磷酸酶、血磷水平、全段甲状旁腺激素、血钙分别为(78.58±2.36)mmol/L、(1.59±0.15)mmol/L、(222.35±5.16)pg/mL、(2.32±0.28)mmol/L,两组比较差异有统计学意义(t=9.032、9.907、8.200、5.751,P<0.001);研究组不良反应为2例(4.65%),对照组12例(27.91%),前者低于后者,差异有统计学意义(χ^(2)=8.531,P=0.003);研究组患者满意度为97.67%,对照组为76.74%,差异有统计学意义(χ^(2)=8.443,P=0.003);研究组患者治疗前后甲状旁腺体积分别为(1.74±0.41)、(0.66±0.11)cm^(3),对照组为(1.78±0.42)、(0.96±0.23)cm^(3),研究组与对照组患者治疗后对比差异有统计学意义(t=7.716,P<0.001)。结论帕立骨化醇与骨化三醇相比,前者治疗效果显著,对继发性甲状旁腺功能亢进症患者具有积极意义。

Objective To analyze the clinical effect of paricalcitol and calcitriol in patients with secondary hyperparathyroidism.Methods 86 patients with secondary hyperparathyroidism received in the hospital from October 2019 to December 2020 were conveniently selected as the evaluation objects.The patients were divided into two groups,namely the study group and the control group(parity grouping method),wiht 43 patients in each group,the former implements paricalcitol treatment measures,the latter implements calcitriol treatment,and evaluates the status and effectiveness of the treatment indicators of the two groups of patients.Results After treatment,patients in the study group had alkaline phosphatase(74.21±2.12)mmol/L,blood phosphorus level(1.28±0.14)mmol/L,full parathyroid hormone(213.26±5.12)pg/mL,and blood calcium(2.72±0.36)mmol/L,the control group alkaline phosphatase,blood phosphorus level,whole parathyroid hormone,blood calcium were(78.58±2.36)mmol/L,(1.59±0.15)mmol/L,(222.35±5.16)pg/mL,(2.32±0.28)mmol/L,respectively,the difference was statistically significant(t=9.032,9.907,8.200,5.751,P<0.001);the adverse reactions of the study group were 2 cases(4.65%),12 cases(27.91%)in the control group,the former was lower than the latter,the difference was statistically significant(χ^(2)=8.531,P=0.003);patient satisfaction in the study group was 97.67%,and the control group was 76.74%,the difference was statistically significant(χ^(2)=8.443,P=0.003);the volume of the parathyroid glands in the study group before and after treatment were(1.74±0.41)cm^(3) and(0.66±0.11)cm^(3),respectively,and the control group was(1.78±0.42)cm^(3),(0.96±0.23)cm^(3),the comparison between the study group and the control group after treatment,the difference was statistically significant(t=7.716,P<0.001).Conclusion Compared with calcitriol,paricalcitol has a significant therapeutic effect and is of positive significance for patients with secondary hyperparathyroidism.