痛风性关节炎患者发生动脉硬化的影响因素分析

Analysis of Influencing Factors of Arteriosclerosis in Patients with Gouty Arthritis

目的研究分析痛风性关节炎患者发生动脉硬化的影响因素。方法随机选取2017年1月—2021年4月该院收治的60例痛风性关节炎患者为研究对象,依据颈动脉有无粥样硬化分组,即动脉粥样硬化组与非动脉粥样硬化组,各30例。对两组患者的临床资料进行统计分析,比较两组一般资料、临床指标水平。结果针对患者性别、体质指数(BMI)、舒张压(DBP)、收缩压(SBP)、受累关节数、有无肾结石、有无痛风石的一般资料,两组比较差异无统计学意义(P>0.05);对于患者年龄、病程的一般资料,动脉粥样硬化组分别为(55.68±3.85)岁、(6.63±1.87)年,均大于非动脉粥样硬化组的(48.69±3.67)岁、(3.95±1.06)年,差异有统计学意义(t=7.198、6.829,P<0.05)。针对患者空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、红细胞沉降率(ESR)的临床指标水平,两组对比差异无统计学意义(P>0.05);对于患者总胆固醇(TC)、血肌酐(SCr)、颈动脉内膜中层厚度(IMT)、尿酸(UA)水平,动脉粥样硬化组分别为(4.68±0.95)mmol/L、(105.16±17.62)μmol/L、(0.84±0.22)mm、(485.26±35.62)μmol/L,非动脉粥样硬化组分别为(4.05±0.92)mmol/L、(84.13±17.06)μmol/L、(0.60±0.16)mm、(401.13±32.62)μmol/L,差异有统计学意义(t=2.609、4.697、4.832、9.540,P<0.05)。结论痛风性关节炎患者发生动脉硬化的影响因素主要有年龄、病程、TC、UA水平等,临床应予以高度重视,以此为防治工作的落实提供指导依据。

Objective To study and analyze the influencing factors of arteriosclerosis in patients with gouty arthritis.Methods 60 patients with gouty arthritis treated in the hospital from January 2017 to April 2021 were randomly selected as the research object.They were divided into atherosclerotic group and non atherosclerotic group according to the presence or absence of carotid atherosclerosis,with 30 cases in each group.The clinical data of the two groups were statistically analyzed,and the general data and clinical index levels of the two groups were compared.Results According to the general data of the patient's gender,body mass index(BMI),diastolic blood pressure(DBP),systolic blood pressure(SBP),number of joints involved,the presence or absence of kidney stones,and the presence or absence of tophi,there was no statistically significant difference between the two groups(P>0.05);for the general data of the patient’s age and course of disease,the values??in the atherosclerosis group were(55.68±3.85)years old and(6.63±1.87)years old,respectively,which were higher than those in the non-atherosclerosis group(48.69±3.67)years old and(3.95±1.06)years old,the difference was statistically significant(t=7.198,6.829,P<0.05).For patients with fasting blood glucose(FPG),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),erythrocyte sedimentation rate(ESR)clinical index levels,two groups had no statistical significance(P>0.05);for patients with total cholesterol(TC),blood creatinine(SCr),carotid artery intima-media thickness(IMT),uric acid(UA),the values of the atherosclerosis group were(4.68±0.95)mmol/L,(105.16±17.62)μmol/L,(0.84±0.22)mm,(485.26±35.62)μmol/L,the values of non-atherosclerosis group were(4.05±0.92)mmol/L,(84.13±17.06)μmol/L,(0.60±0.16)mm,(401.13±32.62)μmol/L,the difference was statistically significant(t=2.609,4.697,4.832,9.540,P<0.05).Conclusion The main influencing factors of arteriosclerosis in patients with gouty arthritis are age,course of disease,TC,UA level,etc.,which should be paid close attention to clinically,so as to provide guidance for the implementation of prevention and treatment.