关节腔内注射玻璃酸钠治疗膝关节骨性关节炎的疗效分析

Analysis of the Curative Effect of Intra-articular Injection of Sodium Hyaluronate in the Treatment of Knee Osteoarthritis

目的分析膝关节骨性关节炎患者采取关节腔内注射玻璃酸钠方案治疗的临床效果与安全性。方法方便选择2018年1月—2020年1月该院收治膝关节骨性关节炎患者101例进行观察分析,以双盲法分组,对照组(n=50)单纯采用药物治疗,观察组(n=51)在其基础上于患者关节腔内注射玻璃酸钠,对比两组治疗效果,观察评估两组患者治疗前后膝关节功能恢复情况,统计两组患者疾病复发率。结果观察组临床治疗总有效率明显高于对照组,差异有统计学意义(χ^(2)=8.466,P<0.05)。治疗后观察组患者跛行评分(2.05±0.43)分、疼痛评分(1.89±0.33)分、肿胀评分(1.93±0.42)分、不稳定评分(2.03±0.25)分均明显低于对照组,差异有统计学意义(t=35.580、43.499、34.067、63.961,P<0.05)。2年内观察组患者复发概率明显低于对照组,差异有统计学意义(χ^(2)=10.027,P<0.05)。结论通过关节腔内注射玻璃酸钠方案治疗膝关节骨性关节炎效果显著,能够有效改善患者膝关节功能,安全性佳,且远期效果好,值得应用推广。

Objective To analyze the clinical effect and safety of intra-articular injection of sodium hyaluronate in patients with knee osteoarthritis.Methods From January 2018 to January 2020,101 patients with knee osteoarthritis were conveniently selected for observation and analysis in the hospital,and they were grouped by double-blind method.The control group(n=50)was treated with drugs alone,and the observation group(n=51)was injected with sodium hyaluronate into the joint cavity of the patients on the basis of it.The treatment effects of the two groups were compared,the knee function recovery of the two groups of patients before and after treatment was observed and evaluated,and the recurrence rate of the two groups of patients was counted.Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group,the difference was statistically significant(χ^(2)=8.466,P<0.05).After treatment,the claudication score(2.05±0.43)points,pain score(1.89±0.33)points,swelling score(1.93±0.42)points,and instability score(2.03±0.25)points of the observation group were significantly lower than those of the control group,the difference was statistically significant(t=35.580,43.499,34.067,63.961,P<0.05).The recurrence probability of patients in the observation group was significantly lower than that in the control group within 2 years,the difference was statistically significant(χ^(2)=10.027,P<0.05).Conclusion Intra-articular injection of sodium hyaluronate is effective in treating knee osteoarthritis.It can effectively improve the knee joint function of patients with good safety and long-term effect.It is worthy of application and promotion.