在新生儿高胆红素血症临床治疗中采用苯巴比妥联合蓝光照射治疗的效果与安全性分析

Analysis of the Effect and Safety of Phenobarbital Combined with Blue Light Irradiation in the Clinical Treatment of Neonatal Hyperbilirubinemia

目的:分析在新生儿高胆红素血症临床治疗中采用苯巴比妥联合蓝光照射治疗的效果与安全性。方法:抽取恩平市人民医院接受治疗的80例高胆红素血症患儿作为观察对象,以数字随机分组法将其分为两组,对照组40例患儿均接受蓝光照射治疗,观察组40例患儿给予苯巴比妥联合蓝光照射治疗。比较两组患儿的黄疸消退时间、血清总胆红素水平和经皮胆红素水平,对比两组患儿的不良反应发生情况。结果:观察组患儿的黄疸消退时间明显短于对照组,其经皮胆红素水平与血清总胆红素水平明显较对照组低差异有统计学意义(t=13.05、9.08、11.75,P<0.05);组间不良反应发生率相比,差异无统计学意义(P>0.05)。结论:苯巴比妥联合蓝光照射治疗新生儿高胆红素血症的临床疗效可观,且安全性较高。

Objective:To analyze the efficacy and safety of phenobarbital combined with blue light irradiation in the clinical treatment of neonatal hyperbilirubinemia.Methods:Eighty children with hyperbilirubinemia who were treated in the hospital were selected as observation objects,and they were divided into two groups by number randomization.40 children in the control group were treated with blue light irradiation,and 40 children in the observation group were treated with phenobarbital combined with blue light irradiation.The jaundice resolution time,serum total bilirubin level and transcutaneous bilirubin level of the two groups of children were compared,and the adverse reactions of the two groups of children were compared.Results:The time for the jaundice to subside in the observation group was significantly shorter than that in the control group,and the percutaneous bilirubin and total serum bilirubin levels were significantly lower than the control group,(t=13.05、9.08、11.75,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the groups(P>0.05).Conclusion:Phenobarbital combined with blue light irradiation is effective in the treatment of neonatal hyperbilirubinemia with high safety.